Serum tumor necrosis factor levels and disease dissemination in leprosy and leishmaniasis.
Serum tumor necrosis factor levels and disease dissemination in leprosy and leishmaniasis.
复制标题
麻风病和利什曼病的血清肿瘤坏死因子水平和疾病传播。
DOI：
10.1093/infdis/161.5.988
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Kiessling,R
中科院分区：
文献类型：
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作者：
Pisa,P;Gennene,M;Söder,O;Ottenhoff,T;Hansson,M;Kiessling,R
肿瘤坏死因子α（TNFα）可能是机体抵抗寄生虫的一种重要的抗原非依赖性防御机制。采用酶联免疫法检测了来自埃塞俄比亚的66例利什曼病患者和68例麻风患者的血清TNFα。已知与特异性T细胞应答缺失或低水平相关的多寄生虫/杆菌型疾病（内脏或弥漫性皮肤利什曼病和瘤型麻风）患者的血清中TNFα滴度显著高于少寄生虫/杆菌型疾病（局限性皮肤利什曼病和非瘤型麻风）患者。在缺乏功能性T细胞应答的情况下，高滴度的TNFα似乎不会产生对埃塞俄比亚利什曼原虫和麻风分枝杆菌的耐药性。
It has been suggested that tumor necrosis factor alpha (TNFα) may serve as an important antigen-independent host defense mechanism against parasitic organisms. Sera from 66 patients with leishmaniasis and 68 patients with leprosy, all from Ethiopia, were tested for TNFα using an enzyme-linked immunoassay. Sera from patients with the multi-parasitic/bacillary type of disease (visceral or diffuse cutaneous leishmaniasis and lepromatous leprosy), known to be associated with absent or low specific T cell response, contained significantly higher TNFα titers than those of patients with pauci-parasitic/bacillary disease (localized cutaneous leishmaniasis and nonlepromatous leprosy). High titers of TNFα in the absence of a functioning T cell response do not appear to confer resistance againstLeishmania aethiopicaandMycobacterium leprae.