Phenotype of microsatellite unstable colorectal carcinomas - Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability
Phenotype of microsatellite unstable colorectal carcinomas - Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability
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DOI：
10.1097/00000478-200305000-00001
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发表时间：
2003-05-01
影响因子：
5.6
通讯作者：
Gruber, SB
中科院分区：
文献类型：
--
作者：
Greenson, JK;Bonner, JD;Gruber, SB
具有微卫星不稳定性的结直肠癌的表型标记物已被广泛研究，包括粘液或低分化。宿主反应突出，生长模式受限。组织学异质性。作为以色列北部以人群为基础的结直肠癌病例对照研究的一部分，我们回顾了528例连续诊断的结直肠癌的病理和微卫星状态。表型分析由一名病理学家（J.K.G.）进行，包括分级、粘液组织学（>50%或局灶性）和组织学异质性的评估。生长模式，坏死和宿主反应。使用5个NCI共识引物确定福尔马林固定石蜡包埋组织的微解剖部分的微卫星状态。528例结直肠癌中微卫星不稳定的52例（9.85%）。多因素分析发现，每高倍视场>2肿瘤浸润淋巴细胞(p
The phenotypic markers of colorectal carcinomas with microsatellite instability have been widely studied and include mucinous or poor differentiation. prominent host response, a circumscribed growth pattern. histologic heterogeneity. and right-sided location, As part of a population-based case-control study of colorectal cancer in northern Israel, we reviewed the pathology and microsatellite status of 528 consecutively diagnosed colorectal cancers. Phenotypic analysis was performed by one pathologist (J.K.G.) and included assessment of grade, mucinous histology (>50%, or focal), histologic heterogeneity. growth pattern, necrosis, and host response. Microsatellite status was determined on microdissected portions of formalin-fixed, paraffin-embedded tissue using a panel of 5 NCI consensus primers. Fifty-two of 528 colorectal carcinomas were microsatellite unstable (9.85%). Multivariate analysis found that >2 tumor infiltrating lymphocytes per high power field (p