Generation of voxelized breast phantoms from surgical mastectomy specimens
Generation of voxelized breast phantoms from surgical mastectomy specimens
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DOI：
10.1118/1.4795758
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发表时间：
2013-04-01
期刊：
影响因子：
3.8
通讯作者：
Glick, Stephen J.
中科院分区：
文献类型：
--
作者：
O'Connor, J. Michael;Das, Mini;Glick, Stephen J.
目的：在研究和开发专用的断层乳腺成像系统中，数字乳腺对象模型，也称为数字体模，是有用的工具。虽然存在各种数字乳房体模，本研究的目的是开发一个逼真的高分辨率模型，适合模拟三维（3D）乳房成像模式。主要目标是设计一个模型，能够产生模拟与现实的乳房组织structure.Methods：用于生成一个合奏的数字乳腺phantomy的方法是基于使用台式，锥形束计算机断层扫描系统的成像手术乳房切除术标本。这种方法允许低噪声，高分辨率的投影视图的乳房切除术标本在每个角位置。重建这些投影集进行处理，使用校正技术和扩散过滤分割成乳腺组织类型，以产生phanimet.Results：8个压缩数字phanimetry和20个未压缩phanimetry，其中一个额外的96个伪压缩数字phanimetry与体素尺寸为0.2毫米（3）。两种不同的组织分类模型用于形成乳房模型。二元模型将每个组织体素分类为脂肪或纤维腺体。多值缩放模型将每个组织体素分类为脂肪组织的百分比（范围1%-99%）。功率谱分析进行比较模拟重建使用的乳房幻影，原来的乳房标本重建，适合被观察到similar.Conclusions：本文开发的数字乳房幻影提供了一个高分辨率的拟人模型的3D未压缩和压缩的乳房，适合用于评估和优化断层乳房成像方式。作者认为，其他研究小组可能会发现幻影有用，因此他们提出让它们更广泛地使用。(C)2013年美国医学物理学家协会。[http：//dx.doi.org/10.1118/1.4795758]
Purpose: In the research and development of dedicated tomographic breast imaging systems, digital breast object models, also known as digital phantoms, are useful tools. While various digital breast phantoms do exist, the purpose of this study was to develop a realistic high-resolution model suitable for simulating three-dimensional (3D) breast imaging modalities. The primary goal was to design a model capable of producing simulations with realistic breast tissue structure.Methods: The methodology for generating an ensemble of digital breast phantoms was based on imaging surgical mastectomy specimens using a benchtop, cone-beam computed tomography system. This approach allowed low-noise, high-resolution projection views of the mastectomy specimens at each angular position. Reconstructions of these projection sets were processed using correction techniques and diffusion filtering prior to segmentation into breast tissue types in order to generate phantoms.Results: Eight compressed digital phantoms and 20 uncompressed phantoms from which an additional 96 pseudocompressed digital phantoms with voxel dimensions of 0.2 mm(3) were generated. Two distinct tissue classification models were used in forming breast phantoms. The binary model classified each tissue voxel as either adipose or fibroglandular. A multivalue scaled model classified each tissue voxel as percentage of adipose tissue (range 1%-99%). Power spectral analysis was performed to compare simulated reconstructions using the breast phantoms to the original breast specimen reconstruction, and fits were observed to be similar.Conclusions: The digital breast phantoms developed herein provide a high-resolution anthropomorphic model of the 3D uncompressed and compressed breast that are suitable for use in evaluating and optimizing tomographic breast imaging modalities. The authors believe that other research groups might find the phantoms useful, and therefore they offer to make them available for wider use. (C) 2013 American Association of Physicists in Medicine. [http://dx.doi.org/10.1118/1.4795758]