Deletion of the ferric uptake regulator fur impairs the in vitro growth and virulence of Actinobacillus pleuropneumoniae
Deletion of the ferric uptake regulator fur impairs the in vitro growth and virulence of Actinobacillus pleuropneumoniae
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DOI：
10.1128/iai.73.6.3740-3744.2005
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发表时间：
2005-06-01
影响因子：
3.1
通讯作者：
Gerlach, GF
中科院分区：
文献类型：
--
作者：
Jacobsen, I;Gerstenberger, J;Gerlach, GF
为了研究铁吸收调节因子 Fur 在猪肺病原体胸膜肺炎放线杆菌中的作用，我们构建了同基因框内缺失突变体，A. pleuropneumoniae Delta Fur。该突变体表现出转铁蛋白结合蛋白的组成型表达、体外生长缺陷以及气溶胶感染模型中毒力降低。
In order to investigate the role of the ferric uptake regulator Fur in the porcine lung pathogen Actinobacillus pleuropneumoniae, we constructed an isogenic in-frame deletion mutant, A. pleuropneumoniae Delta fur. This mutant showed constitutive expression of transferrin-binding proteins, growth deficiencies in vitro, and reduced virulence in an aerosol infection model.