Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells
Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells
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DOI：
10.1126/science.1065543
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发表时间：
2002-01-11
期刊：
影响因子：
56.9
通讯作者：
Glimcher, LH
中科院分区：
文献类型：
--
作者：
Szabo, SJ;Sullivan, BM;Glimcher, LH
T - bet是T盒转录因子家族的一个成员，它似乎部分通过激活标志性的辅助性T细胞1（Th1）细胞因子——干扰素 - γ（IFN - γ）来调节CD4辅助性T（Th）淋巴细胞的谱系定向。IFN - γ也由自然杀伤（NK）细胞产生，并且在CD8细胞毒性T细胞中产生最为显著，它对控制微生物病原体至关重要。尽管T - bet在所有这些细胞类型中都有表达，但它是控制CD4和NK细胞中IFN - γ产生所必需的，而在CD8细胞中则不是。这种差异在这些细胞亚群的功能中也很明显。因此，单一细胞因子IFN - γ的调节在T细胞谱系内是由不同的转录机制所控制的。
T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (T-H) lymphocytes in part by activating the hallmark T(H)1 cytokine, interferon-gamma (IFN-gamma), IFN-gamma is aLso produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital. for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-gamma production in CD4 and NK cells, but not in CD8 cells. This difference is aLso apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage.