ABNORMAL-HEMOGLOBINS IN THE SUDAN SAVANNA OF NIGERIA .1. PREVALENCE OF HEMOGLOBINS AND RELATIONSHIPS BETWEEN SICKLE-CELL TRAIT, MALARIA AND SURVIVAL
ABNORMAL-HEMOGLOBINS IN THE SUDAN SAVANNA OF NIGERIA .1. PREVALENCE OF HEMOGLOBINS AND RELATIONSHIPS BETWEEN SICKLE-CELL TRAIT, MALARIA AND SURVIVAL
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DOI：
10.1080/00034983.1979.11687243
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发表时间：
1979-01-01
影响因子：
--
通讯作者：
ATTAI, EDE
中科院分区：
文献类型：
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作者：
FLEMING, AF;STOREY, J;ATTAI, EDE
研究了尼日利亚卡诺州加尔基不同Hb的流行情况及其与疟疾的相互作用。24%的新生儿和29%的5岁以上儿童存在镰状细胞特征。0.7%的人存在AC。豪萨人两种Hb变异的频率都高于富拉尼人。镰状细胞性贫血在儿童早期几乎总是致命的。Hb的百分比分布曲线。S在镰状细胞特征受试者中是正常的，并且没有显示出任何高频率的α -地中海贫血基因。β的存在。-轻度地中海贫血无法检测，但Hb.S/. β。-地中海贫血未检出。Hb。S基因的频率可能是由杂合子的适合度比正常纯合子高21%维持的；高育性和高突变率没有明显的贡献。Hb。AS受试者的恶性疟原虫滋养体的平均频率和密度明显低于Hb。30-59周AA；3岁以下镰状细胞性状的密度仅在旱季较低。生存优势和镰状细胞特征的流行可能在一些高流行地区最大，而在疟疾传播极高或传播率高且不变的地区则较小。
The prevalence of different Hb and their interaction with malaria were studied in Garki, Kano State, Nigeria. Sickle cell trait was present in 24% of newborns and in 29% of those aged over 5 yr. Hb.AC was present in 0.7%. Frequency of both Hb variants was greater in Hausa than Fulani. Sickle cell anemia was almost invariably fatal in early childhood. The distribution curve of percentage of Hb.S in sickle cell trait subjects was normal, and did not demonstrate any high frequency of a gene for .alpha.-thalassaemia. The presence of .beta.-thalassaemia minor could not be tested, but Hb.S/.beta.-thalassaemia was not detected. Hb.S gene frequency was probably maintained by a fitness in heterozygotes of 21% over normal homozygotes; increased fertility and high mutation rate did not make any apparent contribution. Hb.AS subjects had on average lower frequency and considerably lower densities of Plasmodium falciparum trophozoites than Hb.AA from the age of 30-59 wk; density was less in sickle cell trait up to age 3 yr in the dry season only. The survival advantage and the prevalence of sickle cell trait may be greatest in some hyperendemic areas and less where malaria transmission is extremely high or when it is high and unvaried.