Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone
Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone
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DOI：
10.1079/bjn2001345
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发表时间：
2001-08-01
影响因子：
3.6
通讯作者：
Sorensen, OH
中科院分区：
文献类型：
--
作者：
Brot, C;Vestergaard, P;Sorensen, OH
我们进行了这项研究，以评估正常围绝经期妇女人群中维生素D不足的患病率，检查阳光照射和维生素D摄入量对25-羟基维生素D （25OHD）浓度的影响，并检查甲状旁腺激素（PTH）与25OHD之间的关系。在为期2.5年的丹麦骨质疏松预防研究中，共有2016名年龄在45-58岁之间、最近经历了自然更年期的健康女性被纳入研究。25OHD有明显的季节性波动，6月突然上升，10月前高值。这种波动可能与每月日照时数有关，有两个月的时滞。膳食维生素D摄入量、维生素补充、阳光照射和使用日光浴床都与25OHD浓度显著相关。阳光照射似乎是最大的诱因。维生素D缺乏症（定义为血清250HD = < 25 nmol/l）的总体患病率为7%。而在冬春季节避免阳光直射和不补充维生素D的亚组中，有32.8%的人维生素D缺乏。虽然在血清25OHD低的组中，PTH的平均值升高，但PTH并不是个体维生素D缺乏症的敏感标志，因为只有16%的维生素D缺乏症患者的PTH水平高于正常范围。因此，我们已经表明，如果健康的丹麦中年妇女在夏季避免晒太阳并不补充维生素D，那么她们在冬春季节容易出现维生素D不足。
We conducted this study to assess the prevalence of vitamin D insufficiency in a population of normal perimenopausal women, to examine the influence of sun exposure and vitamin D intake on the concentration of 25-hydroxyvitamin D (25OHD) and to examine the association between parathyroid hormone (PTH) and 25OHD. A total of 2016 healthy women aged 45-58, who had recently undergone a natural menopause, were enrolled over a 2.5-year period in the Danish Osteoporosis Prevention Study. A marked seasonal fluctuation of 25OHD was seen, with an abrupt rise in June and high values until October. The fluctuation could be related to number of hours of sunshine per month with a two months time lag. Dietary vitamin D intake, vitamin supplementation, sunlight exposure, and use of sun-bed were all significantly related to 25OHD concentrations. Sun exposure seemed to contribute the most. The overall prevalence of vitamin D deficiency (defined as serum 250HD = < 25 nmol/l) was 7%. However, in the subgroup avoiding direct sunshine and abstaining from vitamin D supplementation 32.8% were vitamin D deficient in the winter-spring period. Although mean PTH was increased in the group with low serum 25OHD, PTH was not a sensitive marker of hypovitaminosis D in the individual, as only 16% of those with vitamin D deficiency had PTH levels above normal range. Thus, we have shown, that healthy middle-aged Danish women are prone to vitamin D insufficiency in the winter-spring period, if they avoid sun exposure in the summer period and abstain from vitamin D supplementation.