The overlap of interstitial cystitis/painful bladder syndrome and overactive bladder.
The overlap of interstitial cystitis/painful bladder syndrome and overactive bladder.
复制标题
间质性膀胱炎/膀胱疼痛综合征和膀胱过度活动症的重叠。
DOI：
10.4293/108680810x12674612014743
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Chung CW
中科院分区：
文献类型：
--
作者：
Chung MK;Butrick CW;Chung CW
这项研究的结果表明，使用针对尿上皮功能障碍和与间质性膀胱炎相关的神经上调的疗法可能会更有效地治疗膀胱过度活动症治疗失败的患者。我们评估了膀胱过度活动症患者钾敏感性阳性和膀胱镜检查及水扩张结果的患病率。这是一项前瞻性队列研究，纳入了 98 名出现膀胱过度活动症症状的患者。膀胱过度活动症的诊断是通过出现排尿烦躁症状来确定的。所有患者均完成了 PUF 问卷并接受了钾敏感性测试。 80 名患者接受了尿动力学检查，42 名患者在全身麻醉下接受了膀胱镜水扩张。 98 名患者中有 59 名（60.2%）钾敏感试验呈阳性，其中湿性膀胱过度活动症患者 37 名（56%），干性膀胱过度活动症患者 22 名（68.8%）。他们的平均 PUF 评分为 7。接受膀胱镜水扩张的患者中有 33 名 (78.5%) 的肾小球符合 NIH 间质性膀胱炎标准，其中 26 名患者的钾敏感性检测呈阳性。 51 名（63.8%）接受尿动力学检查的患者钾敏感性测试呈阳性。许多患有膀胱过度活动症且几乎没有或没有疼痛的患者有间质性膀胱炎的膀胱镜检查证据和钾敏感试验阳性。针对与间质性膀胱炎/膀胱疼痛综合征相关的尿上皮功能障碍和神经上调的治疗可能是抗胆碱能治疗和行为矫正失败或部分缓解的患者的重要辅助疗法。
Results of this study suggest that patients who have failed therapies for overactive bladder might be more effectively treated using therapies directed towards uroepithelial dysfunction and neural upregulation associated with interstitial cystitis. We evaluated the prevalence of positive potassium sensitivity and cystoscopy with hydrodistention findings in patients with overactive bladder. This was a prospective cohort study of 98 patients who presented with overactive bladder symptoms. The diagnosis of overactive bladder is established by the presence of irritable voiding symptoms. All patients completed a PUF questionnaire and underwent potassium sensitivity testing. Eighty patients underwent urodynamic testing, and 42 patients underwent cystoscopic hydrodistention while under general anesthesia. The Potassium Sensitivity Test was positive in 59 (60.2%) of the 98 patients, 37 (56%) of wet overactive bladder patients, and 22 (68.8%) of dry overactive bladder patients. Their mean PUF score was 7. Thirty-three (78.5%) of the patients who underwent cystoscopic hydrodistention had glomerulations consistent with NIH criteria for interstitial cystitis, and 26 of these patients tested positive for potassium sensitivity. Fifty-one (63.8%) of the patients who underwent urodynamics tested positive for potassium sensitivity. Many patients with symptoms of overactive bladder with little or no pain have cystoscopic evidence of interstitial cystitis and a positive Potassium Sensitivity Test. Therapies directed toward the uroepithelial dysfunction and neural upregulation associated with interstitial cystitis/painful bladder syndrome may be an important adjunct for patients who have failed or have had a partial response to anticholinergic therapy and behavior modification.