Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial
Dose-dependent effects of fish oil on cardio-metabolic biomarkers in healthy middle-aged and elderly Chinese people: a double-blind randomized controlled trial
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鱼油对中国健康中老年人心脏代谢生物标志物的剂量依赖性影响：双盲随机对照试验
DOI：
10.1039/c7fo01566f
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发表时间：
2018
期刊：
影响因子：
6.1
通讯作者：
Mao Limei
中科院分区：
文献类型：
--
作者：
Song Jia;Hu Manjiang;Li Cheng;Yang Bo;Ding Qing;Wang Chunhong;Mao Limei
n-3PUFA 消耗已被广泛接受为心血管疾病 (CVD) 高危患者心血管事件二级预防的营养策略，但人们对普通人群中膳食 n-3PUFA 与心血管健康相关血清生物标志物之间的剂量反应关系知之甚少。本研究涉及一项为期 12 周的双盲、随机对照试验，探讨不同剂量的鱼油（EPA 和 DHA 分别为 0.31、0.62 和 1.24 g d−1）对中国健康中老年人血清脂肪酸和心脏代谢生物标志物（包括脂联素、炎症标志物、血脂和空腹血糖）的影响。 240 名志愿者符合我们的纳入标准。共有 39 名受试者退出，201 名受试者最终完成干预。所有组之间的基线特征和每日膳食营养素摄入量没有显着差异。经过12周的干预后，鱼油剂量依赖性地增强血清EPA、DHA、n-3PUFA和脂联素（0.31 g d−1除外），但降低血清n-6/n-3PUFA、TG和空腹血糖。鱼油组中上述指标从基线到第 12 周的变化与对照组显着不同。同时，所有剂量的EPA和DHA均导致血清CRP下降；仅 1.24 g d−1 就导致 HDL-C 升高，同时 TC/HDL-C 降低，尽管这些变化在所有组中没有显着差异。所有研究结果表明，在膳食 n-3PUFA 摄入不足的健康中老年人中，鱼油剂量依赖性地调节血清 PUFA 和心脏代谢生物标志物，包括脂联素、CRP、血脂和空腹血糖，并且在 1.24 g d−1 时观察到最理想的变化。
n-3PUFA consumption has been widely accepted as a nutritional strategy for the secondary prevention of cardiovascular events in patients at high risk of cardiovascular disease (CVD), but little is known about the dose–response relationship between dietary n-3PUFA and serum biomarkers associated with cardiovascular health in the general population. The present study involved a 12-week double-blind, randomized controlled trial to explore the effects of fish oil with different doses (0.31, 0.62 and 1.24 g d−1 of EPA and DHA) on serum fatty acids and cardio-metabolic biomarkers including adiponectin, inflammatory markers, lipid profiles and fasting glucose in healthy middle-aged and elderly Chinese people. 240 volunteers met our inclusion criteria. A total of 39 subjects dropped out and 201 finally completed the intervention. No significant differences in baseline characteristics and daily intakes of dietary nutrients were detected among all groups. After a 12-week intervention, fish oil dose-dependently enhanced serum EPA, DHA, n-3PUFA and adiponectin (except for 0.31 g d−1), but decreased serum n-6/n-3PUFA, TG and fasting glucose. Changes in the above indicators from the baseline to week 12 in fish oil groups significantly differed from those in the control. Meanwhile, all the doses of EPA and DHA led to decreases in serum CRP; only 1.24 g d−1 led to an increase in HDL-C with a concurrent decrease in TC/HDL-C even though these changes were not significantly different among all groups. All the findings suggested that fish oil dose-dependently regulated serum PUFA and cardio-metabolic biomarkers including adiponectin, CRP, lipid profiles and fasting glucose in healthy middle-aged and elderly Chinese people who consumed insufficient dietary n-3PUFA, and the most desirable changes were observed for 1.24 g d−1.