METHEMOGLOBIN LEVELS IN YOUNG-CHILDREN CONSUMING HIGH NITRATE WELL WATER IN THE UNITED-STATES
METHEMOGLOBIN LEVELS IN YOUNG-CHILDREN CONSUMING HIGH NITRATE WELL WATER IN THE UNITED-STATES
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DOI：
10.1093/ije/10.4.309
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发表时间：
1981-01-01
影响因子：
7.7
通讯作者：
GUNDERSON, DH
中科院分区：
文献类型：
--
作者：
CRAUN, GF;GREATHOUSE, DG;GUNDERSON, DH
EPA [美国环境保护署]对饮用水中硝酸盐（10 mg/l NO3-N）的限制是为了预防婴儿高铁血红蛋白血症，这是一种几乎仅限于3个月以下婴儿的急性疾病。老了这种情况在高铁血红蛋白水平为0.00000时在临床上是可检测的。百分之十苏联的几项研究表明，摄入硝酸盐引起的高铁血红蛋白水平升高可能不仅限于幼儿，并报告了学龄儿童高铁血红蛋白水平升高高达7%与硝酸盐浓度为23-204 mg/l NO3-N的饮用水之间的关联。在美国伊利诺伊州华盛顿县对102名1-8岁儿童进行的流行病学研究表明，摄入硝酸盐浓度为22-111 mg/l NO3-N的水与高铁血红蛋白水平升高无关，儿童高铁血红蛋白水平也不高或高于正常水平。这一地区传染性水传播疾病的可能性得到了证实，因为大部分用于饮用水的威尔斯井含有大量的总大肠菌群和粪大肠菌群。
The EPA [USA-Environmental Protection Agency] limit for nitrate (10 mg/l NO3-N) in drinking water was established to prevent infantile methemoglobinemia, an acute condition confined almost exclusively to infants < 3 mo. old. This condition was clinically detectable at methemoglobin levels of .apprx. 10%. Several studies in the USSR suggested that elevated methemoglobin levels from ingested nitrate may not be confined to the young infant and reported an association between increased methemoglobin levels of up to 7% in schoolchildren and drinking water with a nitrate concentration of 23-204 mg/l NO3-N. An epidemiologic study of 102 children aged 1-8 yr, conducted in Washington County, Illinois [USA], did not show that ingestion of water with a nitrate concentration of 22-111 mg/l NO3-N was related to increasing methemoglobin levels or that the children had high or above normal methemoglobin levels. The potential for transmission of infectious waterborne disease in this area was demonstrated, as a large percentage of the wells used for drinking water contained high numbers of total and fecal coliforms.