The role of host genetics in the susceptibility for HIV-associated neurocognitive disorders.
The role of host genetics in the susceptibility for HIV-associated neurocognitive disorders.
复制标题
宿主遗传学在 HIV 相关神经认知障碍易感性中的作用。
DOI：
10.1007/s10461-008-9360-x
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发表时间：
2009
影响因子：
4.4
通讯作者：
Shapshak,Paul
中科院分区：
文献类型：
--
作者：
Levine,AndrewJ;Singer,ElyseJ;Shapshak,Paul
尽管人类免疫缺陷病毒（HIV）的治疗取得了进展，但受感染的个体仍有很高的患病率，他们会出现神经认知缺陷和障碍。我们对HIV相关神经认知障碍（HAND）的潜在原因的理解继续在许多方面发展。其中之一是宿主遗传学的研究。在这里，我们回顾了关于宿主遗传学与HIV感染，AIDS和HAND风险之间关系的最新信息。我们专注于多巴胺功能障碍在HAND病因学中的作用，并提出了一些与多巴胺能功能和其他神经生物学因素相关的基因内的遗传多态性，这些基因可能赋予HAND的脆弱性或保护作用。
Despite progress in the treatment of the Human Immunodeficiency virus (HIV), there continues to be a high prevalence of infected individuals who develop neurocognitive deficits and disorders. Our understanding of the potential cause of HIV-associated neurocognitive disorders (HAND) continues to develop on many fronts. Among them is the study of host genetics. Here, we review the most current information regarding the association between host genetics and risk for HIV infection, AIDS, and HAND. We focus on the role of dopamine dysfunction in the etiology of HAND, and propose a number of genetic polymorphisms within genes related to dopaminergic functioning and other neurobiological factors that may confer vulnerability or protection against HAND.