The essential role of endogenous IFN α/β in the anti‐metastatic action of sensitized T lymphocytes in mice injected with friend erythroleukemia cells
The essential role of endogenous IFN α/β in the anti‐metastatic action of sensitized T lymphocytes in mice injected with friend erythroleukemia cells
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内源性IFNα/β在注射Friend红白血病细胞的小鼠致敏T淋巴细胞抗转移作用中的重要作用
DOI：
10.1002/ijc.2910630520
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发表时间：
1995
影响因子：
6.4
通讯作者：
F. Belardelli
中科院分区：
文献类型：
--
作者：
I. Gresser;C. Maury;T. Kaido;M. Bandu;M. Tovey;M. Maunoury;L. Fantuzzi;S. Gessani;G. Greco;F. Belardelli
从Friend红白血病细胞（FLC）免疫的DBA/2小鼠中连续转移脾T淋巴细胞，可抑制DBA/2小鼠内脏转移瘤的发生，并延长亲代FLC免疫后24小时至2个月的存活时间。免疫脾细胞在用针对小鼠IFN α/β（但不是针对IFN γ）的强效中和抗体预处理的小鼠中无效，证明内源性IFN α/β在免疫T淋巴细胞对FLC转移的抑制作用中具有重要作用。这些结果表明，报告的免疫T淋巴细胞在免疫缺陷DBA/2突变米色（bg/bg）小鼠中无法发挥抗FLC作用（除非这些小鼠也接受了IFN α/β处理）可能是由于DBA/2 bg/bg小鼠中内源性IFN α/β水平低于正常DBA/2 +/bg小鼠。支持这一假设的实验结果。© 1995 Wiley利斯公司
Adoptive transfer of splenic T lymphocytes from DBA/2 mice immunized against Friend erythroleukemia cells (FLC) inhibited the development of visceral metastases and increased the survival time of DBA/2 mice challenged i.v. with parental FLC 24 hr to 2 months later. Immune spleen cells were ineffective in mice pre‐treated with potent neutralizing antibody to mouse IFN α/β (but not to IFN γ), demonstrating the essential participation of endogenous IFN α/β in the inhibitory action of immune T lymphocytes against FLC metastases. These findings suggest that the reported inability of immune T lymphocytes to exert an anti‐FLC effect in immunodeficient DBA/2 mutant beige (bg/bg) mice (unless these mice had also been treated with IFN α/β), may have been due to lower levels of endogenous IFN α/β in DBA/2 bg/bg mice than in normal DBA/2 +/bg mice. Experimental results in support of this hypothesis are presented. © 1995 Wiley‐Liss, Inc.
巨噬细胞在米色（Chediak-Higashi 综合征）小鼠中发挥作用。
影响因子：
11.2
作者：
Mahoney,KH;Morse,SS;Morahan,PS
通讯作者：
Morahan,PS