Clinical and Metabolic Features of Polycystic Ovary Syndrome among Chinese Adolescents
Clinical and Metabolic Features of Polycystic Ovary Syndrome among Chinese Adolescents
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中国青少年多囊卵巢综合征的临床及代谢特征
DOI：
10.1016/j.jpag.2012.07.006
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发表时间：
2012-12-01
影响因子：
1.8
通讯作者：
Yang, Dongzi
中科院分区：
文献类型：
--
作者：
Li, Lin;Chen, Xiaoli;Yang, Dongzi
目的：探讨中国青少年多囊卵巢综合征（PCOS）的临床和代谢特征，并确定非肥胖和肥胖青少年多囊卵巢综合征患者的差异。设计：临床横断面研究。单位：妇科生殖中心。参与者：25名肥胖和66名非肥胖多囊卵巢综合征青少年和26名年龄匹配的对照组。干预措施：从多囊卵巢综合征患者和对照组中获取空腹静脉血样本和口服葡萄糖耐量试验（75 g葡萄糖）。主要观察指标：总结临床特征。测定血清FSH、LH、E-2、TT、SHBG、空腹胰岛素和空腹血糖水平。结果：PCOS青少年肥胖患病率为27%（25/91）。99%的患者表现为月经紊乱，84%表现为临床和/或生化高雄激素症，90%表现为多囊卵巢超声表现。肥胖PCOS组多毛症和黑棘皮病的患病率高于非肥胖PCOS组（分别为72%对41%和44%对5%）。20名肥胖患者中有5名（25%）和36名非肥胖患者中有5名（14%）表现出葡萄糖耐量水平受损。结论：中国青少年多囊卵巢综合征的临床和代谢特征与中国成年女性多囊卵巢综合征相似，除了高雄激素血症和胰岛素抵抗的患病率增加。有高风险因素的青少年，特别是那些月经紊乱和雄激素过多的青少年，可能需要仔细的临床筛查。
Objectives: To explore the clinical and metabolic features exhibited by Chinese adolescents with polycystic ovary syndrome (PCOS) and to determine the differences between nonobese and obese adolescent patients with PCOS.Design: Clinical cross-sectional study.Setting: Department of Gynecology and Reproductive Center.Participants: 25 obese and 66 nonobese adolescents with PCOS and 26 age-matched controls.Interventions: Fasting venous blood samples and an oral glucose tolerance test using 75 g of glucose were obtained from PCOS patients and controls.Main Outcome Measures: Clinical features were summarized. Serum levels of FSH, LH, E-2, TT, SHBG, fasting insulin, and fasting glucose were measured.Results: The prevalence of obesity in adolescents with PCOS was 27% (25/91). 99% of these patients presented with menstrual disorders, 84% presented with clinical and/or biochemical hyperandrogenism, and 90% exhibited an ultrasonographic appearance of polycystic ovaries. The prevalence of hirsutism and acanthosis nigricans were higher in the obese PCOS group than in the nonobese PCOS group (72% vs 41% and 44% vs 5%, respectively). A total of 5 of 20 obese (25%) and 5 of 36 nonobese patients (14%) demonstrated impaired glucose tolerance levels.Conclusions: Chinese adolescents with PCOS manifest clinical and metabolic features similar to those of adult Chinese women with PCOS except for the increased prevalence of hyperandrogenism and insulin resistance. Adolescents with high risk factors, especially those with menstrual disorders and hyperandrogenism, may need careful clinical screening.