1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors
1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors
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DOI：
10.1016/j.bmcl.2007.02.017
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发表时间：
2007-05-01
影响因子：
2.7
通讯作者：
Augustyns, K.
中科院分区：
文献类型：
--
作者：
Goeminne, A.;McNaughton, M.;Augustyns, K.
合成了一系列新的1,2,3-三唑烷基戊糖醇衍生物，并对其作为核苷水解酶抑制剂进行了评价。最活跃的化合物（11a）具有低微摩尔效价，并且与先前报道的核苷水解酶抑制剂结构不同，这以及其合成化学过程的简单性，使其成为进一步开发新型核苷水解酶抑制剂的良好先导物。(C) 2007 Elsevier Ltd.版权所有。
A range of novel 1,2,3-triazolylalkyiribitol derivatives were synthesized and evaluated as nucleoside hydrolase inhibitors. The most active compound (11a) has low micromolar potency and is structurally diverse from previously reported nucleoside hydrolase inhibitors, which, along with the simplicity of the chemistry involved in its synthesis, makes it a good lead for the further development of novel nucleoside hydrolase inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.