PRELABELED RED NUCLEUS AND SENSORIMOTOR CORTEX NEURONS OF THE RAT SURVIVE 10 AND 20 WEEKS AFTER SPINAL-CORD TRANSECTION
PRELABELED RED NUCLEUS AND SENSORIMOTOR CORTEX NEURONS OF THE RAT SURVIVE 10 AND 20 WEEKS AFTER SPINAL-CORD TRANSECTION
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DOI：
10.1097/00005072-198909000-00007
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发表时间：
1989-09-01
影响因子：
3.2
通讯作者：
WILLIAMS, JK
中科院分区：
文献类型：
--
作者：
MCBRIDE, RL;FERINGA, ER;WILLIAMS, JK
为了明确证明在T-9时完全脊髓横断所切除的红脊髓和皮质脊髓神经元体的命运，我们在年轻成年大鼠的腰椎扩大处注射了一种逆行运输的荧光染料Fluoro-Gold，并在四天后横断脊髓。术后10周和20周细胞数量均未见明显减少。在每种情况下，神经元的平均大小都略有但显著减少。这些发现明确地表明，红脊髓和皮质脊髓系统的长束神经元的躯体持续处于萎缩和可能的失活状态至少20周，并提出了脊髓损伤治疗可能使细胞活性正常化并允许长束再生的可能性。
To demonstrate definitively the fate of the somata of rubrospinal and corticospinal neurons axotomized by a complete spinal cord transection at T-9, in young adult rats we prelabeled the neurons by injection into the lumbar enlargement of a retrogradely transported fluorescent dye, Fluoro-Gold, and four days later transected the cord. We found no loss in cell number ten or 20 weeks after axotomy. The average size of the neurons in each case is slightly but significantly reduced. These findings unequivocally demonstrate that the somata of long tract neurons of the rubrospinal and corticospinal systems persist in an atrophic and presumably inactive state for at least 20 weeks, and raise the possibility that treatment of spinal cord injury may normalize cell activity and allow long tract regeneration.