Biocompatible Coating on Micro-structured Titanium Implants with Enhanced Osteogenesis to Facilitate Bone-implant Integration
Biocompatible Coating on Micro-structured Titanium Implants with Enhanced Osteogenesis to Facilitate Bone-implant Integration
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微结构钛植入物上的生物相容性涂层可增强成骨作用，促进骨植入物整合
DOI：
10.1002/slct.202103540
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发表时间：
2022
期刊：
影响因子：
2.1
通讯作者：
Jian Zhang
中科院分区：
文献类型：
--
作者：
Jiannan Wu;Jing Yang;Yanying Wang;Y;uo Wang;Haiyang Yu;Jing Han;Jian Zhang
钛（Ti）植入物是生物惰性材料。对钛种植体进行表面改性，可以赋予其生物活性，促进其骨结合。在本研究中，钛基质生物相容性的改善主要源于聚多巴胺（PDA）涂层技术，该技术将BMP-2多肽（P24）和明胶膜结合在基质表面。结果表明，P24多肽和明胶膜涂层赋予了钛基体增强的亲水性。与纯钛基体相比，改性后的表面有利于细胞的粘附和铺展，并显著提高了骨髓干细胞（BMSCs）的体外增殖和成骨分化能力。 此外，当钛棒插入大鼠股骨时，改良显著加速了体内骨整合和骨生成。 因此，P24多肽和明胶膜修饰钛种植体表面具有实现快速骨-种植体整合的潜在应用。
Titanium (Ti) implants are bioinert materials. The surface modification of a Ti implant can endow it with biological activity and promote its osteosynthesis. In this study, the improvement of the biocompatibility of Ti substrates mainly originates from polydopamine (PDA) coating technology, which combines the BMP‐2 polypeptide (P24) and a gelatin film on the substrate surface. The results showed that the P24 polypeptide and gelatin film coating endowed the Ti substrate with enhanced hydrophilicity. The modified surface favored cell adhesion and spreading compared with the pure Ti substrate, and significantly improved cell proliferation and osteogenic differentiation of bone marrow stem cells (BMSCs)in vitro. Furthermore, the modification significantly accelerated osseointegration and osteogenesisin vivowhen the Ti rod was inserted into rat femurs. Thus, the P24 polypeptide and gelatin film modification on titanium implant surface has potential applications to achieve rapid bone‐implant integration.