Increased dietary sodium alters neural control of blood pressure during intravenous ANG II infusion.
Increased dietary sodium alters neural control of blood pressure during intravenous ANG II infusion.
复制标题
膳食钠的增加会改变静脉 ANG II 输注过程中血压的神经控制。
DOI：
10.1152/ajpheart.00628.2002
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Bealer,StevenL
中科院分区：
文献类型：
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作者：
Bealer,StevenL
膳食钠的增加会增强对中枢交感神经系统（SNS）中枢刺激的兴奋性和抑制性血压反应。此外，ANG II的长期（数小时至数天）给药通过激活SNS增加血压。这些研究调查了增加饮食钠对SNS控制血压的影响，在0至24小时输注ANG II清醒的雄性大鼠饮用自来水或等渗盐水（Iso）2至3周。在Iso动物中，控制血压和对静脉内ANG II的升压反应的SNS组分（通过用曲美泛进行神经节阻滞评估）均降低。此外，虽然加压反应静脉血管紧张素II输注组之间是相似的，压力感受性反射诱导心动过缓在最初6小时的血管紧张素II输注显着更大，而心动过速伴随较长的输注时间在ISO动物显着减弱。这些数据表明，在正常大鼠增加饮食钠增强交感神经抑制反应在静脉血管紧张素II。
Increased dietary sodium enhances both excitatory and inhibitory blood pressure responses to stimulation of the central sympathetic nervous system (SNS) centers. In addition, long-term (hours to days) administration of ANG II increases blood pressure by activation of the SNS. These studies investigated the effects of increased dietary sodium on SNS control of blood pressure during 0- to 24-h infusion of ANG II in conscious, male rats consuming either tap water or isotonic saline (Iso) for 2 to 3 wk. The SNS component (evaluated by ganglionic blockade with trimetaphan) of both control blood pressure and the pressor response to intravenous ANG II was reduced in Iso animals. Furthermore, although the pressor response to intravenous ANG II infusion was similar between groups, the baroreflex-induced bradycardia during the initial 6 h of ANG II infusion was significantly greater, whereas the tachycardia accompanying longer infusion periods was significantly attenuated in Iso animals. These data suggest that in normal rats increased dietary sodium enhances sympathoinhibitory responses during intravenous ANG II.