Predictors of blastocyst formation rate in elective day 5 transfer cycle
Predictors of blastocyst formation rate in elective day 5 transfer cycle
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DOI：
10.1080/01443615.2019.1676212
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发表时间：
2019-11-29
影响因子：
1.3
通讯作者：
Kim, Seok Hyun
中科院分区：
文献类型：
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作者：
Hong, Yeon Hee;Kim, Hye Kyeong;Kim, Seok Hyun
本研究旨在探讨影响囊胚形成率的因素。选择了107个新鲜体外受精（IVF）和选择性第5天囊胚移植周期。单变量和多变量分析显示，卵胞浆内单精子注射（ICSI）（r = -.236，p = .014 vs. p = .005）有利于囊胚形成。此外，成熟卵母细胞的数量（r = -.274，p = .004 vs. p = .002）是与囊胚和优质囊胚形成率相关的重要因素（p = .021，r = -.389）。ICSI的囊胚和优质囊胚形成率均显著高于常规授精（分别为65.0 +/- 24.5% vs. 50.0 +/-21.2%，p = 0.012; 43.1 +/- 22.8% vs. 30.9 +/-19.8%，p = 0.038）。成熟卵母细胞的数量似乎是最重要的预测囊胚形成率。此外，在囊胚形成率方面，ICSI受精比传统授精有上级优势。影响声明与卵裂移植周期相比，囊胚移植周期具有许多优点，但目前尚无已知的常规胚胎移植时机选择标准。目前认为，囊胚形成的重要因素包括卵裂球数、获卵数、胚胎质量和受精方式。然而，关于这一问题的研究数量有限，一些研究显示了相互矛盾的结果。这项研究的结果增加了什么？本研究表明，成熟卵母细胞数和ICSI受精是影响选择性第5天移植周期囊胚形成率的重要因素。
This study aimed to investigate the factors affecting blastocyst formation rate. One hundred and seven fresh in vitro fertilisation (IVF) and elective day 5 blastocyst transfer cycles were selected. Univariate and multivariate analyses revealed that intracytoplasmic sperm injection (ICSI) (r = -.236, p = .014 vs. p = .005) was advantageous for blastocyst formation. In addition, the number of mature oocytes (r = -.274, p = .004 vs. p = .002) was a significant factor associated with blastocyst and good-quality blastocyst formation rates (p = .021, r = -.389). Both blastocyst and good-quality blastocyst formation rates were significantly higher with ICSI than with conventional insemination (65.0 +/- 24.5% vs. 50.0 +/- 21.2%, p = .012; 43.1 +/- 22.8% vs. 30.9 +/- 19.8%, p = .038, respectively). The number of mature oocytes appears to be the most important predictor of blastocyst formation rate. Additionally, ICSI fertilisation is superior to conventional insemination in terms of blastocyst formation rate.IMPACT STATEMENT What is already known on this subject? There are many advantages of blastocyst transfer cycle over cleavage transfer cycle, but there are no known routine selection criteria for the timing of embryo transfer. To date, the number of blastomeres, number of retrieved oocytes, quality of embryos and fertilisation method have been suggested as the important factors involved in blastocyst formation. However, the number of studies on this issue is limited, and some studies have shown conflicting results. What do the results of this study add? This study showed that the number of mature oocytes and ICSI fertilisation are the significant factors associated with blastocyst formation rate in elective day 5 transfer cycle.