DIMERIZATION OF ERYTHROSE 4-PHOSPHATE
DIMERIZATION OF ERYTHROSE 4-PHOSPHATE
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DOI：
10.1016/0014-5793(76)80288-8
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发表时间：
1976-01-01
期刊：
影响因子：
3.5
通讯作者：
MACLEOD, JK
中科院分区：
文献类型：
--
作者：
BLACKMORE, PF;WILLIAMS, JF;MACLEOD, JK
已推断赤藓糖4-P在非氧化戊糖磷酸途径[11]和光合作用中的碳路径[2]中起关键作用，尽管事实上它从未在任何组织中令人信服地检测和表征。Kornberg和Racker [3]的研究，其中将合成的赤藓糖4-P添加到转醛醇酶和果糖6-P中，以产生公认的产物庚酮糖7-P和丙糖3-P，使假设的“4碳片段”[4]能够被确信地假定为赤藓糖4-P。已报道在克雷布斯腹水肿瘤细胞中赤藓糖4-P的浓度为0.005 nmol/L。在乳腺[6]中，细胞内水浓度为9.2- 13.8 nmol/ml。用于这些估计的转醛醇酶方法[7]留下了怀疑果糖6-P的二羟基丙酮部分的醛受体分子实际上是赤藓糖4-P的余地。核糖5-P将在转醛醇酶催化的反应中反应（1），产生甘油醛3-P，赤藓糖4-P也是如此（2）。
Erythrose 4-P has been inferred to play a key role in the non-oxidative pentose phosphate pathway [11, and in the path of carbon in photosynthesis [2], despite the fact that it has never been convincingly detected and characterized in any tissue. The studies of Kornberg and Racker [3], in which synthetic erythrose 4-P was added to transaldolase and fructose 6-P, to produce the recognized products heptulose 7-P and triose 3-P, enabled the hypothetical ‘4 carbon fragment’[4] to be confidently assumed to be erythrose 4-P.Erythrose 4-P has been reported in Krebs ascites tumour cells at a concentration of 0.005 nmol/g of packed cells [5] and in mammary gland [6] at a concentration of 9.2-l 3.8 nmol/ml of intracellular water. The transaldolase method [7], used for these estimations, leaves room to doubt that the aldo acceptor molecule for the dihydroxyacetone moiety of fructose 6-P was in fact erythrose 4-P. Ribose 5-P will react in the transaldolase catalyzed reaction (1) to give rise to glyceraldehyde 3-P as does erythrose 4-P (2).