Selective sweeps for recessive alleles and for other modes of dominance
Selective sweeps for recessive alleles and for other modes of dominance
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DOI：
10.1007/s00285-010-0382-4
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发表时间：
2010-05
影响因子：
1.9
通讯作者：
Greg Ewing;J. Hermisson;Peter Pfaffelhuber;Johannes Rudolf
中科院分区：
文献类型：
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作者：
Greg Ewing;J. Hermisson;Peter Pfaffelhuber;Johannes Rudolf
选择性扫描描述了由于强正选择而导致的连锁遗传变异的减少。如果 是纯合子对有益等位基因的适应度优势并达到显性系数，则通常假设 h= 1/2，即有益等位基因是共显性的。我们通过假设 [0, 1] 中的任何值来补充选择性扫描的现有理论。我们表明，强度和显性 0 <h< 1 的选择性扫描下的遗传多样性模式与选择强度 2hs 的共显性扫描相似。此外，我们关注完全隐性有益等位基因的 caseh=0。我们发现，如果 N 是种群规模，那么扫描的长度，即从有益等位基因出现到固定的时间，是代数的数量级。模拟以及我们的结果表明，隐性案例中的遗传多样性模式 h= 0 与所有其他案例有很大不同。
A selective sweep describes the reduction of linked genetic variation due to strong positive selection. Ifsis the fitness advantage of a homozygote for the beneficial allele andhits dominance coefficient, it is usually assumed thath= 1/2, i.e. the beneficial allele is co-dominant. We complement existing theory for selective sweeps by assuming thathis any value in [0, 1]. We show that genetic diversity patterns under selective sweeps with strengthsand dominance 0 <h< 1 are similar to co-dominant sweeps with selection strength 2hs. Moreover, we focus on the caseh= 0 of a completely recessive beneficial allele. We find that the length of the sweep, i.e. the time from occurrence until fixation of the beneficial allele, is of the order ofgenerations, ifNis the population size. Simulations as well as our results show that genetic diversity patterns in the recessive caseh= 0 greatly differ from all other cases.