Opposing Influence of Sensory and Motor Cortical Input on Striatal Circuitry and Choice Behavior
Opposing Influence of Sensory and Motor Cortical Input on Striatal Circuitry and Choice Behavior
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DOI：
10.1016/j.cub.2019.03.028
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发表时间：
2018-10
期刊：
影响因子：
9.2
通讯作者：
Christian R. Lee;Alex J. Yonk;J. Wiskerke;K. Paradiso;J. Tepper;David J. Margolis
中科院分区：
文献类型：
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作者：
Christian R. Lee;Alex J. Yonk;J. Wiskerke;K. Paradiso;J. Tepper;David J. Margolis
纹状体是基底神经节的主要输入核，是感觉运动整合的关键部位。虽然纹状体从大脑皮层接受广泛的兴奋性传入，但不同皮质区域对纹状体回路和行为的影响尚不清楚。在这里，我们发现，来自胡须相关初级躯体感觉(S1)和运动(M1)皮质的皮质纹状体输入对背侧纹状体的投射神经元和中间神经元有不同的神经支配作用，并对感觉引导行为产生相反的影响。光遗传刺激S1-皮质纹状体传入神经元inex在纹状体小白蛋白(PV)表达的中间神经元上产生比表达D1或D2的棘突投射神经元(SPN)更大的突触后电位，这一效应在M1-皮质纹状体传入神经元中未观察到。关键的是，在对S1-皮质纹状体传入的活体光遗传刺激中，产生了任务特异性的行为抑制，这是由纹状体PV中间神经元双向调节的。对M1传入的光遗传刺激产生了相反的行为效应。因此，我们的结果表明，感觉皮质和运动皮质通过对纹状体回路的不同影响而在行为选择中扮演相反的角色。
The striatum is the main input nucleus of the basal ganglia and is a key site of sensorimotor integration. While the striatum receives extensive excitatory afferents from the cerebral cortex, the influence of different cortical areas on striatal circuitry and behavior is unknown. Here, we find that corticostriatal inputs from whisker-related primary somatosensory (S1) and motor (M1) cortex differentially innervate projection neurons and interneurons in the dorsal striatum and exert opposing effects on sensory-guided behavior. Optogenetic stimulation of S1-corticostriatal afferents inex vivorecordings produced larger postsynaptic potentials in striatal parvalbumin (PV)-expressing interneurons than D1- or D2-expressing spiny projection neurons (SPNs), an effect not observed for M1-corticostriatal afferents. Critically,in vivooptogenetic stimulation of S1-corticostriatal afferents produced task-specific behavioral inhibition, which was bidirectionally modulated by striatal PV interneurons. Optogenetic stimulation of M1 afferents produced the opposite behavioral effect. Thus, our results suggest opposing roles for sensory and motor cortex in behavioral choice via distinct influences on striatal circuitry.