Junceols D-H, new polyoxygenated briaranes from sea whip gorgonian coral Junceella juncea (Ellisellidae)
Junceols D-H, new polyoxygenated briaranes from sea whip gorgonian coral Junceella juncea (Ellisellidae)
复制标题
DOI：
10.1248/cpb.56.1276
复制
发表时间：
2008-09-01
影响因子：
1.7
通讯作者：
Sheu, Jyh-Horng
中科院分区：
文献类型：
--
作者：
Sung, Ping-Jyun;Pai, Chen-Hao;Sheu, Jyh-Horng
通过对海鞭柳珊瑚Junceella juncea的化学研究，分离出5个新的8-羟基briarane二萜类化合物，即Junceols D-H（1-5）。根据光谱方法确定了briaranes 1-5的结构，发现亚甲基环己烷环以船形存在于这些新的二萜中。Junceols D（1）和F-H（3-5）对CCRF-CEM和DLD-1肿瘤细胞具有细胞毒性，Junceols E-H（2-5）对人中性粒细胞产生超氧阴离子具有弱抑制作用。
Chemical investigations on the sea whip gorgonian coral Junceella juncea have led to the isolation of five new 8-hydroxybriarane diterpenoids, junceols D-H (1-5). The structures of briaranes 1-5 were determined on the basis of spectroscopic methods and the methylenecyclohexane rings were found to exist in boat form in these new diterpenoids. Junceols D (1) and F-H (3-5) exhibited cytotoxicity toward CCRF-CEM and DLD-1 tumor cells and junceols E-H (2-5) displayed weak inhibitory effects on superoxide anion generation by human neutrophils.