Optical coherence tomography imaging of the inner ear: A feasibility study with implications for cochlear implantation
Optical coherence tomography imaging of the inner ear: A feasibility study with implications for cochlear implantation
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DOI：
10.1177/000348940811700503
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发表时间：
2008-05-01
影响因子：
1.4
通讯作者：
Jafri, M. Samir
中科院分区：
文献类型：
--
作者：
Lin, James;Staecker, Hinrich;Jafri, M. Samir
现在，在有残余听力的耳朵中进行耳蜗植入术。那些保留残余听力的植入物接受者可以通过电听力和声学听力从改善的音高分辨率中受益。人工耳蜗植入后耳蜗功能的保护对外科医生来说是一项具有挑战性的任务。目前听力保护研究的主题包括电极设计和手术技术。为了保持听力，外科医生努力创建耳蜗造口术并以最小创伤的方式放置电极。在这项研究中，我们研究了一种新的基于导管的实时成像模式，分辨率为10至15 μ m，光学相干断层扫描（OCT），对内耳。我们证明了光学相干断层扫描的能力，使内耳结构的可视化通过骨在活的小鼠。我们还使用OCT对人颞骨中的内耳进行成像。光学相干断层扫描能够描绘耳蜗内的软组织结构，并可能是有用的辅助人工耳蜗植入。OCT的其他潜在的耳科应用进行了讨论。
Cochlear implantation is now being performed in ears with residual hearing. Those implant recipients who keep residual hearing may benefit from improved pitch resolution through both electrical and acoustic hearing. Preservation of cochlear function after implantation is a challenging task for the surgeon. Current topics of hearing preservation research include electrode design and surgical technique. To maintain hearing, surgeons strive to create a cochleostomy and place the electrode in a minimally traumatic fashion. In this study, we examine a novel catheter-based real-time imaging modality with 10- to 15-mu m resolution, optical coherence tomography (OCT), on the inner ear. We demonstrate the capability of OCT to allow visualization of inner ear structures through bone in live mice. We additionally used OCT to image the inner ear in a human temporal bone. Optical coherence tomography was able to delineate soft tissue structures within the cochlea and may be useful as an adjunct to cochlear implantation. Other potential otologic applications of OCT are discussed.