Gentle Touch Therapy, Pain Relief and Neuroplasticity at Baseline in Fibromyalgia Syndrome: A Randomized, Multicenter Trial with Six-Month Follow-Up.
Gentle Touch Therapy, Pain Relief and Neuroplasticity at Baseline in Fibromyalgia Syndrome: A Randomized, Multicenter Trial with Six-Month Follow-Up.
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DOI：
10.3390/jcm11164898
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发表时间：
2022-08-20
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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背景：纤维肌痛（FM）被认为是一种应激相关的疾病，主要特征是慢性广泛性疼痛。其发病机制尚不清楚，但累积的证据表明，功能失调的递质系统和炎症生物标志物可能是该疾病的主要症状的基础。本研究旨在评估接受轻柔触摸疗法（GTT）或安慰剂治疗的FM女性患者的疼痛评分（主要结局）、生活质量、炎症生物标志物和神经递质系统（次要结局）。方法：将64例女性FM患者随机分为GTT组（n = 32）和安慰剂组（n = 32）。在基线和干预后6个月随访时进行临床评估。我们测量了血清儿茶酚胺（多巴胺），吲哚胺和中间代谢物（5-羟色胺或5-羟基吲哚乙酸（5-HIAA）），以及四氢生物蝶呤（BH 4），这是一个辅因子的合成神经递质和炎症生物标志物的女性FM。一组没有干预的健康个体（对照组）用于比较生化测量。干预效果进行了分析，使用重复测量（RM）的双向方差分析，然后由Bonferroni事后检验和混合ANCOVA模型与意向treat. Results：相比，安慰剂，GTT组提出了较低的疼痛评分和脑源性神经营养因子（BDNF）水平，而不改变FM的妇女的生活质量。BDNF的变化在疼痛中具有介导作用。较高的基线血清BDNF和5-HIAA或那些有焦虑症病史的人显示出随着时间的推移疼痛评分的降低幅度更大。然而，ANCOVA混合模型显示，基线时血清多巴胺水平较高的女性在整个观察期内的干预效果较低。结论：总之，与安慰剂组相比，GTT组观察到较低的疼痛评分，而不会改变FM女性的生活质量。BDNF水平的降低可能是FM疼痛状态改善的机制。从这个意义上说，本研究鼓励使用这些GTT技术作为FM的综合和补充治疗。
Background: Fibromyalgia (FM) is considered a stress-related disorder characterized mainly by chronic widespread pain. Its pathogenesis is unknown, but cumulative evidence points at dysfunctional transmitter systems and inflammatory biomarkers that may underlie the major symptoms of the condition. This study aimed to evaluate pain scores (primary outcome), quality of life, inflammatory biomarkers and neurotransmitter systems in women with FM (secondary outcomes) subjected to gentle touch therapy (GTT) or placebo. Methods: A total of 64 female patients with FM were randomly assigned to two groups, namely GTT (n = 32) or Placebo (n = 32). Clinical assessments were conducted at baseline and post-intervention with six-month follow-up. We measured serum catecholamines (dopamine), indolamines and intermediary metabolites (serotonin or 5-hydroxyindolacetic acid (5-HIAA)), as well as tetrahydrobiopterin (BH4), which is a cofactor for the synthesis of neurotransmitters and inflammatory biomarkers in women with FM. A group of healthy individuals with no intervention (control group) was used to compare biochemical measurements. Intervention effects were analyzed using repeated measures (RM) two-way ANOVA followed by Bonferroni post hoc test and mixed ANCOVA model with intention to treat. Results: Compared to placebo, the GTT group presented lower pain scores and brain-derived neurotrophic factor (BDNF) levels without altering the quality of life of women with FM. Changes in BDNF had a mediating role in pain. Higher baseline serum BDNF and 5-HIAA or those with a history of anxiety disorder showed a higher reduction in pain scores across time. However, women with higher serum dopamine levels at baseline showed a lower effect of the intervention across the observation period revealed by an ANCOVA mixed model. Conclusions: In conclusion, lower pain scores were observed in the GTT group compared to the placebo group without altering the quality of life in women with FM. Reductions in BDNF levels could be a mechanism of FM pain status improvement. In this sense, the present study encourages the use of these GTT techniques as an integrative and complementary treatment of FM.
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影响因子：
2.9
作者：
Caumo W;Deitos A;Carvalho S;Leite J;Carvalho F;Dussán-Sarria JA;Lopes Tarragó Mda G;Souza A;Torres IL;Fregni F
通讯作者：
Fregni F
影响因子：
64.8
作者：
Cronin SJF;Seehus C;Weidinger A;Talbot S;Reissig S;Seifert M;Pierson Y;McNeill E;Longhi MS;Turnes BL;Kreslavsky T;Kogler M;Hoffmann D;Ticevic M;da Luz Scheffer D;Tortola L;Cikes D;Jais A;Rangachari M;Rao S;Paolino M;Novatchkova M;Aichinger M;Barrett L;Latremoliere A;Wirnsberger G;Lametschwandtner G;Busslinger M;Zicha S;Latini A;Robson SC;Waisman A;Andrews N;Costigan M;Channon KM;Weiss G;Kozlov AV;Tebbe M;Johnsson K;Woolf CJ;Penninger JM
通讯作者：
Penninger JM
影响因子：
8.9
作者：
Clauw, Daniel J.
通讯作者：
Clauw, Daniel J.
影响因子：
2.9
作者：
Deitos, Alicia;Dussan-Sarria, Jairo A.;Caumo, Wolnei
通讯作者：
Caumo, Wolnei
影响因子：
5.3
作者：
Dur, Sadiye;Caglar, Seda;Varal, Ipek Guney
通讯作者：
Varal, Ipek Guney