A surrogate-based metaheuristic global search method for beam angle selection in radiation treatment planning.
A surrogate-based metaheuristic global search method for beam angle selection in radiation treatment planning.
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DOI：
10.1088/0031-9155/58/6/1933
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发表时间：
2013-03-21
影响因子：
3.5
通讯作者：
Meyer RR
中科院分区：
文献类型：
--
作者：
Zhang HH;Gao S;Chen W;Shi L;D'Souza WD;Meyer RR
癌症治疗的放射治疗计划的一个重要因素是选择光束角度（在所有可能的共面和非共面角度中），以便最大限度地向肿瘤部位输送辐射，并最大限度地减少对附近危险器官的辐射损伤。这类组合优化问题特别困难，因为直接评估与任何建议的光束选择相对应的治疗质量需要解决涉及数千个变量的大规模剂量优化问题，这些变量代表了患者体内体积单元（体素）的剂量。然而，如果能够在不耗费大量计算的情况下准确估计角度集的质量，则可以考虑大量的角度集，从而增加识别非常高质量集的可能性。使用基于从使用等间距光束（eplans）的平面图中提取的单光束数据的计算效率的代理光束集评估程序，我们开发了基于嵌套分区框架的全局搜索元启发式过程来解决该组合优化问题。代理评分机制使我们能够在临床可接受的时间框架内评估数千个束集样本。临床疑难病例试验表明，采用本方法获得的光束组质量较好。
An important element of radiation treatment planning for cancer therapy is the selection of beam angles (out of all possible coplanar and non-coplanar angles in relation to the patient) in order to maximize the delivery of radiation to the tumor site and minimize radiation damage to nearby organs-at-risk. This category of combinatorial optimization problem is particularly difficult because direct evaluation of the quality of treatment corresponding to any proposed selection of beams requires the solution of a large-scale dose optimization problem involving many thousands of variables that represent doses delivered to volume elements (voxels) in the patient. However, if the quality of angle sets can be accurately estimated without expensive computation, a large number of angle sets can be considered, increasing the likelihood of identifying a very high quality set. Using a computationally efficient surrogate beam set evaluation procedure based on single-beam data extracted from plans employing equally-spaced beams (eplans), we have developed a global search metaheuristic process based on the Nested Partitions framework for this combinatorial optimization problem. The surrogate scoring mechanism allows us to assess thousands of beam set samples within a clinically acceptable time frame. Tests on difficult clinical cases demonstrate that the beam sets obtained via our method are superior quality.
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