Successful Remembering Elicits Event-Specific Activity Patterns in Lateral Parietal Cortex
Successful Remembering Elicits Event-Specific Activity Patterns in Lateral Parietal Cortex
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DOI：
10.1523/jneurosci.4328-13.2014
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发表时间：
2014-06-04
影响因子：
5.3
通讯作者：
Chun, Marvin M.
中科院分区：
文献类型：
--
作者：
Kuhl, Brice A.;Chun, Marvin M.
回忆过去的事件涉及在高级感知区域（例如，腹侧颞叶皮层（VTC）。相比之下，生动记忆的主观体验通常与侧顶叶皮层（LPC）的活动增加有关-“检索成功效应”被认为是跨内容类型的概括。然而，LPC激活在记忆提取过程中的功能意义仍然是一个积极的辩论的主题。特别地，关于LPC是否主动地表示检索到的内容或者LPC活动是否仅与其他地方的内容重新激活成比例（例如，职业训练局）。在这里，我们报告了人类的视觉记忆回忆（面孔与场景）的功能磁共振成像研究，其中互补形式的多体素模式分析被用来测试和比较LPC和VTC内的内容再激活。在视觉图像的回忆，我们观察到强大的再激活的广泛类别的信息（脸与场景）在VTC和LPC。此外，在LPC，但不是VTC，召回相关的活动模式，个别事件之间的差异。重要的是，这些内容的影响是特别明显的LPC（即，角回），其中活动规模与主观报告的回忆生动。这些发现提供了惊人的证据，证明LPC不仅表明记忆已成功回忆，而且还积极地代表了所记住的内容。
Remembering a past event involves reactivation of content-specific patterns of neural activity in high-level perceptual regions (e.g., ventral temporal cortex, VTC). In contrast, the subjective experience of vivid remembering is typically associated with increased activity in lateral parietal cortex (LPC)-"retrieval success effects" that are thought to generalize across content types. However, the functional significance of LPC activation during memory retrieval remains a subject of active debate. In particular, theories are divided with respect to whether LPC actively represents retrieved content or if LPC activity only scales with content reactivation elsewhere (e.g., VTC). Here, we report a human fMRI study of visual memory recall (faces vs scenes) in which complementary forms of multivoxel pattern analysis were used to test for and compare content reactivation within LPC and VTC. During recall of visual images, we observed robust reactivation of broad category information (face vs scene) in both VTC and LPC. Moreover, recall-related activity patterns in LPC, but not VTC, differentiated between individual events. Importantly, these content effects were particularly evident in areas of LPC (namely, angular gyrus) in which activity scaled with subjective reports of recall vividness. These findings provide striking evidence that LPC not only signals that memories have been successfully recalled, but actively represents what is being remembered.