DQA1 and DQB1 association and nasal polyposis
DQA1 and DQB1 association and nasal polyposis
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DOI：
10.1016/j.otohns.2006.03.034
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发表时间：
2006-08-01
影响因子：
3.4
通讯作者：
Olivo-Diaz, Angelica
中科院分区：
文献类型：
--
作者：
Fajardo-Dolci, German;Solorio-Abreu, Jesus;Olivo-Diaz, Angelica
OBJECTIVE: The aim of this study was to determine the contribution of the human major histocompatibility complex (HLA)-DQA1 -DQB1, and TNF alpha genes with simple nasal polyposis.STUDY DESIGN AND SETTING: A comparative case-control study with 31 patients and 151 controls was performed. HLA-DQA1 -DQB1, and TNF alpha -238 promoter position loci were typed by polymerase chain reaction (PCR) and sequence specific oligonucleotide probes (SSOPs). TNF alpha -308 promoter position was determined by PCR and digestion with NcoI restriction enzyme.RESULTS: The allele HLA-DQA1*0201 (P-c = 0.019) had an etiologic fraction (EF) of 17%, whereas 13% EF was found for the haplotype HLA-DQA1*0201-DQB1*0201 (P = 0.016). Analysis of -DQB1 and TNF alpha promoter did not show significant differences between cases and controls.CONCLUSIONS: HLA-DQA1*0201-DQB1*0201 haplotype is involved in susceptibility, conferring 5.53 times more risk of developing this disease.
