Effects of Tritrichomonas muris on the Mouse Intestine: A Proteomic Analysis
Effects of Tritrichomonas muris on the Mouse Intestine: A Proteomic Analysis
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DOI：
10.1538/expanim.58.537
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发表时间：
2009-10-01
影响因子：
2.4
通讯作者：
Shibahara, Toshiyuki
中科院分区：
文献类型：
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作者：
Kashiwagi, Akiko;Kurosaki, Hajime;Shibahara, Toshiyuki
鼠毛滴虫是包括小鼠在内的实验动物中常见的寄生虫，但其在宿主动物中的发病机制尚不清楚。蛋白质组学可用于特异性分析宿主-寄生虫相互作用和宿主对寄生虫的免疫反应。然而，蛋白质组学尚未应用于T鼠研究。本文用蛋白质组学分析了T鼠对宿主的影响。我们发现，与未感染的小鼠肠道相比，感染T小鼠肠道中表达了10种不同的蛋白质。所鉴定的蛋白具有多种功能，主要与应激、免疫应答、代谢和信号转导有关。结果表明，T鼠感染可能影响小鼠肠道对感染引起的环境变化的适应过程。
Although Tritrichomonas muris is a common parasite often detected in experimental animals including mice, its pathogenesis in host animals remains unclear. Proteomics can be used to specifically analyze biochemical host-parasite interaction and immune responses of the host to parasites. However, proteomics have not yet been applied to T muris studies. Here, the effects of T muris on the host were analyzed by proteomics. We found that 10 different proteins were expressed in T muris-infected mice intestines compared with noninfected intestines. The identified proteins represented several functions mainly related to stress, immune response, metabolism and signal transduction. The results suggest that T muris infection may affect processes that are acclimatizing to the environmental changes caused by the infection in the mouse intestine.