Gender-related differences in IBS symptoms
Gender-related differences in IBS symptoms
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DOI：
10.1016/s0002-9270(01)02524-2
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发表时间：
2001-07-01
影响因子：
9.8
通讯作者：
Naliboff, B
中科院分区：
文献类型：
--
作者：
Lee, OY;Mayer, EA;Naliboff, B
目的：女性比男性更容易报告肠易激综合征（IBS）症状以及慢性内脏和肌肉骨骼疼痛。该研究验证了一般假设，即女性IBS患者与男性患者在内脏和肌肉骨骼系统相关的症状上存在差异，这些差异与月经周期有关。方法：对714例Rome阳性IBS患者进行GI和结肠外症状、心理症状（SCL-90R）和生活质量（QOL） （SF-36）的评估。此外，54名绝经后妇女与61名绝经前妇女和54名年龄匹配的伴侣进行比较，均患有肠易激综合征。结果：男性和女性受试者报告的GI症状水平相似；严重程度和心理问题。与腹胀感相关的腹胀在女性患者中更为常见，便秘症状也是如此。女性患者更常报告恶心、味觉和嗅觉改变、舌头不愉快的感觉、早晨肌肉僵硬、对食物更敏感以及药物副作用。40%的女性患者报告了与月经周期相关的症状恶化，但在绝经前和绝经后妇女之间几乎没有发现症状差异，因此观察到的大多数性别差异不太可能与月经周期直接相关。结论：尽管IBS严重程度、腹痛、心理症状和疾病影响水平相似，但女性患者报告的各种肠道和非肠道感觉症状水平较高。对非疼痛性内脏感觉、药物和食物敏感性的明显差异可能代表感觉过程、自主神经反应和/或认知过度警觉的改变。(C) 2001由Am。科尔。胃肠病学。
OBJECTIVE: Women are more likely than men to report irritable bowel syndrome (IBS) symptoms as well as chronic visceral and musculoskeletal pain. The study tests the general hypothesis that female IBS patients differ from their male counterparts in symptoms related to the viscera and musculoskeletal system, and that these differences are related to the menstrual cycle.METHODS: Seven hundred fourteen Rome positive IBS patients were evaluated for GI and extracolonic symptoms, psychological symptoms (SCL-90R), and quality of Life (QOL) (SF-36). In addition, 54 postmenopausal women were compared with 61 premenopausal women and 54 age-matched mates, all with IBS.RESULTS: Male and female subjects reported similar GI levels of symptom;severity and psychological problems. Abdominal distension associated with a sensation of bloating was more commonly reported by female patients, as were symptoms of constipation. Female patients more often reported nausea, alterations of taste and smell, and unpleasant sensations on the tongue, muscle stiffness in the morning, greater food sensitivity, and side effects from medications. Forty percent of female patients reported menstrual cycle-related worsening of symptoms, but few symptom differences were found between pre- and postmenopausal women, making it unlikely that most of the gender differences observed are directly tied to the menstrual cycle.CONCLUSIONS: Female patients report higher levels of a variety of intestinal and nonintestinal sensory symptoms despite similar levels of IBS severity, abdominal pain, psychological symptoms, and illness impact. The apparent differences in sensitivity to nonpainful visceral sensations, medications, and food may represent altered sensory processes, autonomic responses, and/or cognitive hypervigilance. (C) 2001 by Am. Coll. of Gastroenterology.