THE ORIGIN AND FATE OF TWO TYPES OF MULTI-NUCLEATED GIANT CELLS IN THE CIRCULATING BLOOD.
THE ORIGIN AND FATE OF TWO TYPES OF MULTI-NUCLEATED GIANT CELLS IN THE CIRCULATING BLOOD.
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DOI：
10.1084/jem.52.2.279
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发表时间：
1930-07-31
期刊：
影响因子：
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通讯作者：
Forkner CE
中科院分区：
文献类型：
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作者：
Forkner CE
1. 已证实可诱导异物和上皮样巨细胞出现在血流中。 2. 已有证据表明，异物巨细胞主要由单核细胞融合形成，并且至少在某些情况下，这些巨细胞的命运是通过分离成组成元素来完成的。 3. 进一步的证据已经提出，支持“上皮样巨细胞”达到其进化阶段的假设，不是通过单核细胞的融合，而是通过单核细胞和上皮样细胞的细胞核的有丝分裂。 4. 由于琼脂注射的结果，外周血中存在巨细胞几乎总是与显着的单核细胞增多相关，或先于显着的单核细胞增多，其中新的单核细胞尺寸较大并显示出不成熟的证据。 5.将琼脂注射到组织中会导致淋巴细胞的绝对值和百分比值降低，并且许多多形核白细胞中的特定颗粒减少。 6. 从这些研究看来，血液中的“上皮样巨细胞”和“异物巨细胞”通常是可能明显分化的，但另一方面，可能存在一些具有每种类型的一些特征的细胞。后面这些细胞可能在其形成过程中代表了单个细胞的融合和单核细胞核的有丝分裂。 7. 在极少数情况下，发现裂细胞或巨噬细胞参与异物巨细胞的形成。至少有一个例子表明，一个裂变细胞与几个单核细胞融合。没有证据表明巨噬细胞在“上皮样巨细胞”的形成中发挥过作用。
1. It has been demonstrated that giant cells of the foreign body and epithelioid types can be induced to appear in the blood stream. 2. Evidence has been presented which indicates that foreign body giant cells are primarily formed by fusion of monocytes and that the fate of these giant cells is accomplished, at least in some instances, by a separation into the constituent elements. 3. Further evidence has been presented which lends support to the hypothesis that "epithelioid giant cells" reach their stage of evolution, not by fusion of monocytes, but by amitotic division of the nuclei of monocytes and epithelioid cells. 4. The presence of giant cells in the peripheral blood as the result of agar injections is almost invariably associated with, or preceded by a marked monocytosis in which the new monocytes are of large size and show evidence of immaturity. 5. Injections of agar into the tissues result in decreased absolute and percentage values of lymphocytes and a diminution of the specific granules in many of the polymorphonuclear leucocytes. 6. It would appear from these studies that a clear differentiation of "epithelioid giant cells" and "foreign body giant cells" in the blood is usually possible, but that on the other hand, a few cells may be present which have some of the characteristics of each type. These latter cells probably represent in their formation both a fusion of individual cells and an amitotic division of the nuclei of monocytes. 7. Clasmatocytes or macrophages have in rare instances been seen to take part in the formation of foreign body giant cells. At least one instance has been noted of the fusion of a clasmatocyte with several monocytes. No evidence is available to demonstrate that macrophages ever play a part in the formation of "epithelioid giant cells."