The genetics of obesity and the metabolic syndrome.
The genetics of obesity and the metabolic syndrome.
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DOI：
10.2174/187153010791213100
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Kraja AT
中科院分区：
文献类型：
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作者：
Monda KL;North KE;Hunt SC;Rao DC;Province MA;Kraja AT
在这篇综述中，我们讨论了肥胖和代谢综合征的遗传结构，突出了最近的进展，在确定遗传变异和基因座负责的一部分，在肥胖性状，血清HDL和甘油三酯，血压和血糖性状的变化，换句话说，组成代谢综合征的组件。我们特别关注大规模全基因组关联研究的最新进展。详细介绍他们的成功经验，以及如何吸取教训，为未来的发现铺平道路。最近的全基因组关联研究结果与早期的工作相结合，表明肥胖和代谢综合征之间存在许多相互联系，这些联系是通过几种潜在的多效性效应发展起来的。我们详细介绍了最近的工作，通过一个案例研究的钙粘蛋白13基因及其与脂联素在HyperGEN和心脏研究，其与肥胖和代谢综合征的关系。我们还提供了通过全基因组关联研究发现的与肥胖和代谢综合征相关的最新变异的基因网络分析。
In this review, we discuss the genetic architecture of obesity and the metabolic syndrome, highlighting recent advances in identifying genetic variants and loci responsible for a portion of the variation in adiposity traits, serum HDL and triglycerides, blood pressure, and glycemic traits; in other words, the components comprising the metabolic syndrome. We focus particularly on recent progress from large-scale genome-wide association studies. Detailing their successes and how lessons learned can pave the way for future discovery. Results from recent genome-wide association studies coalesce with earlier work suggesting numerous interconnections between obesity and the metabolic syndrome, developed through several potentially pleiotropic effects. We detail recent work by way of a case study on the cadherin 13 gene and its relation with adiponectin in the HyperGEN and the Framingham Heart Studies, and its association with obesity and the metabolic syndrome. We provide also a gene network analysis on recent variants related to obesity and metabolic syndrome discovered through genome-wide association studies.