Performance of the amyotrophic lateral sclerosis functional rating scale (ALSFRS) in multicenter clinical trials
Performance of the amyotrophic lateral sclerosis functional rating scale (ALSFRS) in multicenter clinical trials
复制标题
DOI：
10.1016/s0022-510x(97)00237-2
复制
发表时间：
1997-10-01
影响因子：
4.4
通讯作者：
Stambler, N
中科院分区：
文献类型：
--
作者：
Cedarbaum, JM;Stambler, N
肌萎缩侧索硬化症功能评定量表（ALSFRS）是一个10项功能调查表，设计用于ALS的治疗试验。每个项目由患者和/或护理人员在0-4量表上评分，最高得分为40分。ALSFRS评估患者在喂养方面的自给自足水平。仪容仪表，仪表和交流。ALSFRS的旋转因素分析发现，评级项目组逻辑和一贯分为四类。ALSFRS已通过肌肉力量测试、Schwab和England ADL评定量表、临床总体印象变化（CGIC）量表和患者功能状态独立评估的横截面和纵向验证。在这份报告中，我们使用的数据：提供的安慰剂患者参加ALS CNTF治疗研究（ALS），以证明的鲁棒性，重测信度和一致性的ALSFRS在一个大型的，多中心的临床试验。(C)1997年Elsevier Science B.V.
The Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) is a 10-item functional inventory which was devised for use in therapeutic trials in ALS. Each item is rated on a 0-4 scale by the patient and/or caregiver, yielding a maximum score of 40 points. The ALSFRS assesses patients' levels of self-sufficiency in areas of feeding. grooming, ambulation and communication. Rotated factor analysis of the ALSFRS found that the rating items group logically and consistently into four categories. The ALSFRS has been validated both cross-sectionally and longitudinally against muscle strength testing, the Schwab and England ADL rating scale, the Clinical Global Impression of Change (CGIC) scale, and independent assessments of patient's functional status. In this report, we use the data: provided by the placebo patients who participated in the ALS CNTF Treatment Study (ACTS) to demonstrate the robustness, test-retest reliability and consistency of the ALSFRS as employed in a large, multicenter clinical trial. (C) 1997 Elsevier Science B.V.