The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue.
The role of dopamine in schizophrenia from a neurobiological and evolutionary perspective: old fashioned, but still in vogue.
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DOI：
10.3389/fpsyt.2014.00047
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发表时间：
2014
影响因子：
4.7
通讯作者：
Gos T
中科院分区：
文献类型：
--
作者：
Brisch R;Saniotis A;Wolf R;Bielau H;Bernstein HG;Steiner J;Bogerts B;Braun K;Jankowski Z;Kumaratilake J;Henneberg M;Gos T
多巴胺是一种与精神分裂症病理学有关的抑制性神经递质。修正后的多巴胺假说认为，精神分裂症患者存在中脑边缘和前额叶脑区的多巴胺异常。然而，最近的研究表明，谷氨酸、GABA、乙酰胆碱和5-羟色胺的改变也参与了精神分裂症的病理过程。本文综述了多巴胺在精神分裂症动物模型中的作用及其与认知功能的关系。此外，这篇综述不仅概述了多巴胺受体和针对它们的治疗的抗精神病作用，而且还概述了多巴胺及其与其他精神分裂症神经化学模型的相互作用。多巴胺的作用，在人类大脑的进化和人类的精神能力，这是精神分裂症患者的影响，也进行了讨论。
Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and prefrontal brain regions exist in schizophrenia. However, recent research has indicated that glutamate, GABA, acetylcholine, and serotonin alterations are also involved in the pathology of schizophrenia. This review provides an in-depth analysis of dopamine in animal models of schizophrenia and also focuses on dopamine and cognition. Furthermore, this review provides not only an overview of dopamine receptors and the antipsychotic effects of treatments targeting them but also an outline of dopamine and its interaction with other neurochemical models of schizophrenia. The roles of dopamine in the evolution of the human brain and human mental abilities, which are affected in schizophrenia patients, are also discussed.
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影响因子：
4.1
作者：
Abi-Dargham, Anissa;Xu, Xiaoyan;Slifstein, Mark
通讯作者：
Slifstein, Mark
影响因子：
0.9
作者：
Arai, Shinsaku;Shibata, Hiroki;Fukumaki, Yasuyuki
通讯作者：
Fukumaki, Yasuyuki
DOI：
10.1016/j.ijdevneu.2011.02.006
发表时间：
2011-05
影响因子：
1.8
作者：
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作者：
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通讯作者：
Moran, P. M.
影响因子：
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作者：
Balla, Andrea;Schneider, Samantha;Javitt, Daniel C.
通讯作者：
Javitt, Daniel C.