Late-stage macrolactonisation enabled by tandem acyl transfers followed by desulphurisation
Late-stage macrolactonisation enabled by tandem acyl transfers followed by desulphurisation
复制标题
通过串联酰基转移和脱硫实现后期大内酯化
DOI：
10.1039/d1cc07248j
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发表时间：
2022
影响因子：
4.9
通讯作者：
Otaka Akira
中科院分区：
文献类型：
--
作者：
Sato Daiki;Denda Masaya;Tsunematsu Honoka;Tanaka Naonobu;Konishi Isamu;Komiya Chiaki;Shigenaga Akira;Otaka Akira
分子内S-酰化的巯基安装的苏氨酸与硫酯单元，然后通过S-O酰基转移和随后的脱乙酰化，允许内酯肽的合成。已经开发了一种能够使线性肽环化的方案，这是一种通过常规方法无法实现的反应。
Intramolecular S-acylation of a thiol-installed threonine with a thioester unit, followed by S–O acyl transfer and subsequent desulphurisation, allows the synthesis of lactone peptides. A protocol has been developed enabling the cyclisation of a linear peptide, a reaction which has not been achieved by conventional methods.