New loci associated with chronic hepatitis B virus infection in Han Chinese
New loci associated with chronic hepatitis B virus infection in Han Chinese
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汉族慢性乙型肝炎病毒感染相关新位点
DOI：
10.1038/ng.2809
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发表时间：
2013-12-01
期刊：
影响因子：
30.8
通讯作者：
Shen, Hongbing
中科院分区：
文献类型：
--
作者：
Hu, Zhibin;Liu, Yao;Shen, Hongbing
慢性B型肝炎病毒（HBV）感染是一个具有挑战性的全球性健康问题。为了确定慢性HBV感染相关的基因位点，我们设计了一项中国汉族人群的三阶段全基因组关联研究。发现阶段包括951名HBV携带者（病例）和937名自然清除HBV感染的个体（对照），随后是独立重复，共有2，248名病例和3，051名对照，以及来自普通人群的1，982名HBV携带者和2，622名对照。我们发现了两个与慢性HBV感染相关的新位点：位于6p21.33的rs3130542（接近HLA-C，比值比（OR）= 1.33，P = 9.49 x 10（-14））和位于22q11.21的rs 4821116（在UBE 2L 3中，OR = 0.82，P = 1.71 x 10（-12））。此外，我们重复了先前确定的6p21.32处HLA-DP和HLA-DQ变异与慢性HBV感染的相关性。这些发现突出了HLA-C和UBE 2L 3在清除HBV感染中除了HLA-DP和HLA-DQ之外的重要性。
Chronic hepatitis B virus (HBV) infection is a challenging global health problem. To identify genetic loci involved in chronic HBV infection, we designed a three-phase genome-wide association study in Han Chinese populations. The discovery phase included 951 HBV carriers (cases) and 937 individuals who had naturally cleared HBV infection (controls) and was followed by independent replications with a total of 2,248 cases and 3,051 controls and additional replications with 1,982 HBV carriers and 2,622 controls from the general population. We identified two new loci associated with chronic HBV infection: rs3130542 at 6p21.33 (near HLA-C, odds ratio (OR) = 1.33, P = 9.49 x 10(-14)) and rs4821116 at 22q11.21 (in UBE2L3, OR = 0.82, P = 1.71 x 10(-12)). Additionally, we replicated the previously identified associations of HLA-DP and HLA-DQ variants at 6p21.32 with chronic HBV infection. These findings highlight the importance of HLA-C and UBE2L3 in the clearance of HBV infection in addition to HLA-DP and HLA-DQ.