Polygenic risk scores for asthma and allergic disease associate with COVID-19 severity in 9/11 responders.
Polygenic risk scores for asthma and allergic disease associate with COVID-19 severity in 9/11 responders.
复制标题
DOI：
10.1371/journal.pone.0282271
复制
发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
Luft, Benjamin J.
中科院分区：
文献类型：
--
作者：
Waszczuk, Monika A.;Morozova, Olga;Lhuillier, Elizabeth;Docherty, Anna R.;Shabalin, Andrey A.;Yang, Xiaohua;Carr, Melissa A.;Clouston, Sean A. P.;Kotov, Roman;Luft, Benjamin J.
遗传因素导致2019冠状病毒病（COVID-19）严重程度的个体差异。一部分遗传易感性可以使用多基因风险评分（PRS）来捕获。关于PRS与社区居民中COVID-19严重程度或急性期后COVID-19之间的关联，人们知之甚少。这项研究的参与者是983名首次感染SARS-CoV-2的世贸中心应答者（感染时的平均年龄= 56.06岁; 93.4%为男性; 82.7%为欧洲血统）。75名（7.6%）应答者属于严重COVID-19类别; 306名（31.1%）在4周随访时报告了至少一种急性后COVID-19症状。对人群分层和人口统计学协变量进行了调整。哮喘PRS与重度COVID-19类别（比值比[OR] = 1.61，95%置信区间：1.17-2.21）和更严重的COVID-19疾病（β = 0.09，p = 0.01）相关，与呼吸系统疾病诊断无关。严重COVID-19类别也与过敏性疾病PRS（OR = 1.97，[1.26-3.07]）和COVID-19住院PRS（OR = 1.35，[1.01-1.82]）相关。冠状动脉疾病和II型糖尿病的PRS与COVID-19的严重程度无关。最近开发的哮喘、过敏性疾病和COVID-19住院治疗的多基因生物标志物捕捉了社区人群中COVID-19疾病严重程度和临床病程的一些个体差异。
Genetic factors contribute to individual differences in the severity of coronavirus disease 2019 (COVID-19). A portion of genetic predisposition can be captured using polygenic risk scores (PRS). Relatively little is known about the associations between PRS and COVID-19 severity or post-acute COVID-19 in community-dwelling individuals. Participants in this study were 983 World Trade Center responders infected for the first time with SARS-CoV-2 (mean age at infection = 56.06; 93.4% male; 82.7% European ancestry). Seventy-five (7.6%) responders were in the severe COVID-19 category; 306 (31.1%) reported at least one post-acute COVID-19 symptom at 4-week follow-up. Analyses were adjusted for population stratification and demographic covariates. The asthma PRS was associated with severe COVID-19 category (odds ratio [OR] = 1.61, 95% confidence interval: 1.17–2.21) and more severe COVID-19 symptomatology (β = .09, p = .01), independently of respiratory disease diagnosis. Severe COVID-19 category was also associated with the allergic disease PRS (OR = 1.97, [1.26–3.07]) and the PRS for COVID-19 hospitalization (OR = 1.35, [1.01–1.82]). PRS for coronary artery disease and type II diabetes were not associated with COVID-19 severity. Recently developed polygenic biomarkers for asthma, allergic disease, and COVID-19 hospitalization capture some of the individual differences in severity and clinical course of COVID-19 illness in a community population.
登录
查看更多内容
影响因子：
7.7
作者：
通讯作者：
--
影响因子：
20.1
作者：
van der Harst P;Verweij N
通讯作者：
Verweij N
DOI：
10.1093/bioinformatics/btu848
发表时间：
2015-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Euesden J;Lewis CM;O'Reilly PF
通讯作者：
O'Reilly PF
影响因子：
8.7
作者：
Ober C;Yao TC
通讯作者：
Yao TC
影响因子：
16.6
作者：
Xue A;Wu Y;Zhu Z;Zhang F;Kemper KE;Zheng Z;Yengo L;Lloyd-Jones LR;Sidorenko J;Wu Y;eQTLGen Consortium;McRae AF;Visscher PM;Zeng J;Yang J
通讯作者：
Yang J