Prospective study of changes in sugar-sweetened beverage consumption and the incidence of the metabolic syndrome and its components: the SUN cohort
Prospective study of changes in sugar-sweetened beverage consumption and the incidence of the metabolic syndrome and its components: the SUN cohort
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DOI：
10.1017/s0007114513000822
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发表时间：
2013-11-14
影响因子：
3.6
通讯作者：
Bes-Rastrollo, Maira
中科院分区：
文献类型：
--
作者：
Barrio-Lopez, Maria T.;Martinez-Gonzalez, Miguel A.;Bes-Rastrollo, Maira
代谢综合征 (MetS) 的发病率正在增加，生活方式可能起了一定作用。本研究的目的是前瞻性评估西班牙大学毕业生群体中含糖饮料 (SSB) 消费量的变化与 MetS 及其组成部分的发病率之间的关联。我们纳入了 8157 名最初没有参加 MetS 的参与者，并进行了至少 6 年的随访。 SSB 消耗量是通过先前在西班牙验证的 FFQ 收集的。 SSB 消耗量的变化计算为 6 年随访时 SSB 消耗量与基线消耗量之间的差异。 MetS 是根据国际糖尿病联合会和美国心脏协会/国家心肺血液研究所对 MetS 的新定义来定义的，该新定义统一了之前的定义。使用多元逻辑回归检查 SSB 摄入量变化与 MetS 之间的关联。我们观察了 361 起 MetS 事件。增加 SSB 摄入量（上五分位数与下五分位数）的参与者发生 MetS 的风险显着更高（调整后 OR 2 .2，95% CI 1.4、3.5；趋势 P 0.003）。同样，他们患高血压（调整后 OR 1.6，95% CI 1.3、2.1）、向心性肥胖（调整后 OR 2.3，95% CI 1.9、2.7）、高三酰甘油血症（调整后 OR 1.7，95% CI 1.1、2.6）或空腹血糖受损（调整后 OR 1.6，95% CI）的风险显着升高。 1.1、2.2）。总之，对地中海地区的大学毕业生进行了 6 年的随访后，SSB 摄入量的增加与罹患 MetS 和其他代谢性疾病的较高风险相关。
The incidence of the metabolic syndrome (MetS) is increasing and lifestyle behaviours may play a role. The aim of the present study was to prospectively assess the association between changes in the consumption of sugar-sweetened beverages (SSB) and the incidence of the MetS and its components in a Spanish cohort of university graduates. We included 8157 participants initially free of the MetS and followed up during at least 6 years. SSB consumption was collected by a FFQ previously validated in Spain. The change in SSB consumption was calculated as the difference between SSB consumption at a 6-year follow-up and baseline consumption. The MetS was defined according to the International Diabetes Federation and the American Heart Association/ National Heart, Lung, and Blood Institute's new definition of the MetS that had harmonised previous definitions. The associations between changes in SSB intake and the MetS were examined using multiple logistic regression. We observed 361 incident cases of the MetS. Participants who increased their consumption of SSB (upper v. lower quintile) had a significantly higher risk of developing the MetS (adjusted OR 2 .2, 95% CI 1.4, 3.5; P for trend 0.003). Similarly, they presented a significantly higher risk of developing high blood pressure (adjusted OR 1.6, 95% CI 1.3, 2.1), central obesity (adjusted OR 2.3, 95% CI 1.9, 2.7), hypertriacylglycerolaemia (adjusted OR 1.7, 95% CI 1.1, 2.6) or impaired fasting glucose (adjusted OR 1.6, 95% CI 1.1, 2.2). In conclusion, an increase in SSB consumption was associated with a higher risk of developing the MetS and other metabolic disorders after 6 years of follow-up in a Mediterranean cohort of university graduates.