Effects of stress and the sympathetic nervous system on coronary artery atherosclerosis in the cynomolgus macaque.
Effects of stress and the sympathetic nervous system on coronary artery atherosclerosis in the cynomolgus macaque.
复制标题
应激和交感神经系统对食蟹猴冠状动脉粥样硬化的影响。
DOI：
10.1016/0002-8703(88)90110-x
复制
发表时间：
1988
影响因子：
4.8
通讯作者：
Clarkson,TB
中科院分区：
文献类型：
--
作者：
Manuck,SB;Kaplan,JR;Adams,MR;Clarkson,TB
流行病学证据越来越多地表明心理社会变量与人类冠心病的发展有关，这种关联似乎独立于其他冠状动脉疾病危险因素的影响。有人假设，行为对冠心病的影响是通过交感神经系统的激活来调节的，可能是通过冠状动脉粥样硬化的恶化。本文综述了在非人类灵长类动物的动脉粥样硬化形成模型中，应激和交感神经兴奋对动脉粥样硬化的影响的几项研究。与被安置在固定(稳定)成员群体中的对照动物相比，应用涉及社会群体成员定期重组的行为应激源导致雄性食蟹猴(食蟹猴)的冠状动脉粥样硬化恶化，但仅限于在研究过程中保持主导社会地位的猴子。这种影响不能归因于伴随的血压或血脂浓度的变化。当同样的实验程序被应用于喂食低饱和脂肪和低胆固醇饮食的男性时，对群体成员的操纵类似地导致冠状动脉中更大的动脉粥样硬化。在相关的观察中，对标准化行为挑战表现出最大心率反应的猴子比对压力表现出较不明显心脏反应的动物有更广泛的冠状动脉粥样硬化。在最后一次调查中，我们观察到，长期服用β肾上腺素受体阻滞剂盐酸普萘洛尔可以预防在不稳定的社会群体中食用致动脉粥样硬化饮食的主要猴子的动脉粥样硬化加剧。
Epidemiologic evidence increasingly implicates psychosocial variables in the development of coronary heart disease in human beings, an association that appears to be independent of the effects of other coronary disease risk factors. It has been hypothesized that behavioral influences on coronary heart disease are mediated by activation of the sympathetic nervous system, perhaps through exacerbation of coronary artery atherosclerosis. This article summarizes several studies of the effects of stress and sympathetic arousal on atherosclerosis in a nonhuman primate model of atherogenesis. The application of a behavioral stressor involving periodic reorganization of social group memberships resulted in worsened coronary atherosclerosis among male cynomolgus monkeys (Macaca fascicularis) fed a cholesterol-containing diet, relative to control animals housed in groups of fixed (stable) membership, but only among those monkeys that retained dominant social status during the course of the study. This effect could not be attributed to concomitant variability in blood pressure or serum lipid concentrations. When the same experimental procedures were applied to males fed a diet low in saturated fat and cholesterol, the manipulation of group memberships similarly led to development of greater atherosclerosis in the coronary arteries. In related observations, monkeys that exhibited the largest heart rate responses to a standardized behavioral challenge had more extensive coronary atherosclerosis than animals showing a less pronounced cardiac responsivity to stress. In a final investigation, we observed that the exacerbated atherosclerosis of dominant monkeys consuming an atherogenic diet and housed in unstable social groups could be prevented by long-term administration of a β-adrenoreceptor-blocking agent, propranolol hydrochloride.