CONGESTIVE HEART-FAILURE WITH NORMAL SYSTOLIC FUNCTION
CONGESTIVE HEART-FAILURE WITH NORMAL SYSTOLIC FUNCTION
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DOI：
10.1016/s0002-9149(84)80207-6
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发表时间：
1984-01-01
影响因子：
2.8
通讯作者：
GOLDSTEIN, RA
中科院分区：
文献类型：
--
作者：
DOUGHERTY, AH;NACCARELLI, GV;GOLDSTEIN, RA
尽管有关于收缩功能正常的充血性心力衰竭（CHF）的孤立报道，但此前尚未描述过这种情况的患病率和特征。因此，对 188 名接受放射性核素心室造影的 CHF 患者进行了前瞻性评估。 67 例 (36%) 的射血分数 (EF) 正常为 0.45 或更高，121 例 EF < 0.45 异常。其中，72 例（55 例 EF 异常 [组 I] 和 17 例 EF 正常 [组 II]）也接受了临床特征评估。各组之间没有人口统计学差异，只是系统性高血压似乎是 II 组 65% 患者的一个促成因素，而 I 组这一比例为 23%（P < 0.002）。在 72 名患者和 14 名正常受试者中测定了反映左心室顺应性的超声心动图左心房排空指数。正常对照受试者的左心房排空指数为0.93±。 0.11 (.+-.SD)，相比之下 0.41 .+-.第一组 0.18，0.44 .+-。 II 组患者为 0.19（与对照组相比，P < 0.001）。因此，CHF 患者的收缩功能正常是很常见的。两个 CHF 组均发现舒张功能障碍，与左心室不顺应一致。
Although there have been isolated reports of congestive heart failure (CHF) with normal systolic function, the prevalence and characteristics of this condition have not previously been described. Accordingly, 188 patients with CHF undergoing radionuclide ventriculography were prospectively evaluated. Sixty-seven (36%) had a normal ejection fraction (EF) of 0.45 or greater, and 121, an abnormal EF of < 0.45. Of these, 72 (55 with an abnormal EF [group I] and 17 with a normal EF [group II]) were also reviewed for clinical characteristics. There was no demographic difference between groups, except that systemic hypertension appeared to be a contributing factor in 65% of the patients in group II, compared with 23% of the patients in group I (P < 0.002). Echocardiographic left atrial emptying index, reflecting left ventricular compliance, was determined in 72 patients and 14 normal subjects. Left atrial emptying index in normal control subjects was 0.93 .+-. 0.11 (.+-. SD), compared with 0.41 .+-. 0.18 in group I and 0.44 .+-. 0.19 in group II patients (P < 0.001 vs. control in both groups). Thus, normal systolic function is common among patients with CHF. Diastolic dysfunction, consistent with a noncompliant left ventricle, was found in both CHF groups.