Antibodies to hair follicles in alopecia areata.
Antibodies to hair follicles in alopecia areata.
复制标题
斑秃毛囊抗体。
DOI：
10.1111/1523-1747.ep12375477
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Bystryn,JC
中科院分区：
文献类型：
--
作者：
Tobin,DJ;Orentreich,N;Fenton,DA;Bystryn,JC
虽然斑秃被怀疑是一种自身免疫性疾病，但没有直接证据表明对毛囊成分的免疫反应发生了改变。我们研究了斑秃患者是否存在正常人头发生长期毛囊的抗体。用Western免疫印迹法检测39份斑秃患者血清和27份对照血清中抗正常毛发生长期头皮毛囊6M尿素提取蛋白的抗体。在1：80稀释的血清中，所有斑秃受试者（100%），但只有44%的对照个体，具有针对一种或多种约57、52、50、47或44 kD抗原的抗体。斑秃患者个体毛囊抗原抗体的发生率比对照血清高7倍，其水平高13倍，对所有5种抗原均具有统计学显著性。组织特异性分析表明，这些抗原选择性地表达于毛囊中，提示斑秃患者存在针对毛囊抗原的异常抗体，支持斑秃是一种自身免疫性疾病的假说。
Although alopecia areata is suspected to be an autoimmune disease, no direct evidence of an altered immune response to components of the hair follicle has been reported. We studied whether antibodies to normal human anagen scalp hair follicles are present in individuals with alopecia areata. Thirty- nine alopecia areata sera and 27 control sera were tested by Western immunoblotting for antibodies to 6 M urea- extractable proteins of normal anagen scalp hair follicles. At serum diluted 1:80, all alopecia areata subjects (100%), but only 44% of control individuals, had antibodies directed to one or more antigens of approximately 57, 52, 50, 47, or 44 kD. The incidence of antibodies to individual hair follicle antigens in alopecia areata was up to seven times more frequent than in control sera and their level up to 13 times greater and was statistically significant for all five antigens. Tissue specificity analysis indicated that these antigens were selectively expressed in hair follicles.These findings indicate that individuals with alopecia areata have abnormal antibodies directed to hair follicle antigens, and support the hypothesis that alopecia areata is an autoimmune disease.
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影响因子：
--
作者：
Tobin,DJ;Orentreich,N;Bystryn,JC
通讯作者：
Bystryn,JC
脱发的免疫学方面。
DOI：
10.1111/1523-1747.ep12858178
发表时间：
1991
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Bystryn,JC;Tamesis,J
通讯作者：
Tamesis,J
疱疹样皮炎皮肤中的 IgA 结合结构独立于弹性微原纤维束。
DOI：
10.1111/1523-1747.ep12515903
发表时间：
1991
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Lightner,VA;Sakai,LY;Hall,RP
通讯作者：
Hall,RP
Mr 75,000 细胞表面人类黑色素瘤相关抗原的鉴定和纯化。
影响因子：
11.2
作者：
J. Heaney;J. Bystryn
通讯作者：
J. Bystryn
影响因子：
--
作者：
F. Helm;H. Milgrom
通讯作者：
H. Milgrom