Ketamine contributes to the alteration of Ca2+ transient evoked by behavioral tests in the prelimbic area of mPFC: A study on chronic CORT-induced depressive mice
Ketamine contributes to the alteration of Ca2+ transient evoked by behavioral tests in the prelimbic area of mPFC: A study on chronic CORT-induced depressive mice
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氯胺酮有助于改变 mPFC 前边缘区域行为测试引起的 Ca2 瞬变：一项对慢性 CORT 诱导的抑郁小鼠的研究
DOI：
10.1016/j.neulet.2020.135220
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发表时间：
2020-06
影响因子：
2.5
通讯作者：
Hui Shen
中科院分区：
文献类型：
--
作者：
Yuanyuan Li;Tianyu Yu;Qi Hu;Feifei Wang;Shiyang Yuan;Cui Li;Juping Li;Jialin Cui;Hui Shen
近年来的研究表明，氯胺酮是一种快速有效的抗抑郁药，但其抗抑郁作用的机制尚不完全清楚。体内给予氯胺酮后抑郁样行为与特定脑区神经元活动的关系尚缺乏研究。内侧前额叶皮层（mPFC）参与抑郁症的发病机制。由于行为测试后的有效评估，大多数研究缺乏疗效与特定脑区活动之间关系的直接证据。因此，我们使用纤维光度法研究了自由运动小鼠行为测试中mPFC边缘前区（PrL） Ca2+瞬态的变化。我们的研究结果表明，慢性皮质酮（CORT）方案诱导抑郁样行为。氯胺酮的使用逆转了这些作用。在行为测试中，Ca2+瞬态的激活与一些行为有关。挣扎、养育和探索引起了强烈的Ca2+瞬变，但移动和梳理没有。氯胺酮可逆转CORT诱导的挣扎、饲养和探索的Ca2+瞬态振幅降低。结果表明，氯胺酮通过介导PrL的神经激活来改善抑郁样行为。
Recent studies have showed that ketamine is a rapid and efficient antidepressant, but the mechanism of its antidepressant effect is not fully clear. It is still lack of the research investigating the relation between depressive-like behaviors and neuronal activities in specific brain area after administration of ketamine in vivo. Medial prefrontal cortex (mPFC) involved in the pathogenesis of depression. As a result of effective assessments after behavioral test, most studies lack of direct evidence of the relation between efficacy and the activity of specific brain area. Therefore, we used fiber photometry to explore the alteration of Ca2+transient in the prelimbic (PrL) area of mPFC during behavioral tests in freely moving mice. Our results showed that the chronic corticosterone (CORT) protocol induced depressive-like behaviors. Administration of ketamine reversed these effects. The activation of Ca2+transients was associated with some behaviors during behavioral tests. Struggling, rearing and exploring evoked strong Ca2+transients, but moving and grooming did not. The Ca2+transients amplitude reductions of struggling, rearing and exploring induced by CORT were reversed by ketamine. The results indicated that ketamine ameliorated depressive-like behaviors via mediating neural activation in PrL.
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影响因子：
3.4
作者：
Jett JD;Boley AM;Girotti M;Shah A;Lodge DJ;Morilak DA
通讯作者：
Morilak DA
影响因子：
10.6
作者：
Brachman RA;McGowan JC;Perusini JN;Lim SC;Pham TH;Faye C;Gardier AM;Mendez-David I;David DJ;Hen R;Denny CA
通讯作者：
Denny CA
DOI：
10.1016/j.scitotenv.2019.06.250
发表时间：
2019-11
期刊：
The Science of the total environment
影响因子：
--
作者：
Jie Yu;Weihong Xu;Ya Luo;W. Ou;Shengnan Li;Xu Chen;Jie Xu
通讯作者：
Jie Yu;Weihong Xu;Ya Luo;W. Ou;Shengnan Li;Xu Chen;Jie Xu
影响因子：
2.7
作者：
Boman, Lindsey;De Butte, Maxine
通讯作者：
De Butte, Maxine
DOI：
10.3390/ijerph120910450
发表时间：
2015-08-27
影响因子：
--
作者：
Caplan S;Buyske S
通讯作者：
Buyske S