Intranasal oxytocin in obsessive-compulsive disorder
Intranasal oxytocin in obsessive-compulsive disorder
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DOI：
10.1016/0006-3223(96)00120-5
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发表时间：
1996-09-15
影响因子：
10.6
通讯作者：
Price, LH
中科院分区：
文献类型：
--
作者：
Epperson, CN;McDougle, CJ;Price, LH
研究催产素对强迫症（OC）症状的影响，使用明显更高剂量的鼻内催产素。据推测，更高的剂量可能使足够量的催产素穿过血脑屏障并产生行为效应。7名患有强迫症的成人（平均年龄46.3岁）接受鼻内催产素1周和生理盐水安慰剂1周。7名受试者中有5名接受了分4次每日剂量的催产素。两个S通过加倍的吹入次数接受了两倍的剂量。结果表明，最大剂量的鼻内催产素没有影响OC症状。（PsycINFO数据库记录（c）2018阿帕，保留所有权利）
Investigated the effects of oxytocin on obsessive compulsive (OC) symptoms using significantly higher doses of intranasal oxytocin. It was hypothesized that higher dosages might enable a sufficient amount of oxytocin to cross the blood brain barrier and have behavioral effects. Seven adults (mean age 46.3 yrs) with obsessive compulsive disorder received intranasal oxytocin for 1 wk and saline placebo for 1 wk. Five of the 7 Ss received oxytocin divided in 4 daily doses. Two Ss received twice this dosage by doubling the number of insufflations. Results reveal that maximal doses of intranasal oxytocin did not effect OC symptoms.(PsycINFO Database Record (c) 2018 APA, all rights reserved)