Recurrent genital herpes simplex virus infection in guinea pigs.
Recurrent genital herpes simplex virus infection in guinea pigs.
复制标题
豚鼠复发性生殖器单纯疱疹病毒感染。
DOI：
10.1159/000149647
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发表时间：
1985
期刊：
影响因子：
4.6
通讯作者：
OverallJr,JC
中科院分区：
文献类型：
--
作者：
Stanberry,LR;Kern,ER;Richards,JT;OverallJr,JC
从初始生殖器单纯疱疹病毒（HSV）感染中恢复后，雌性豚鼠发生自发性复发性感染，其特征为外生殖器皮肤上的离散疱疹性或水疱性疱疹性病变。单纯疱疹病毒2型（HSV 2）引起的豚鼠复发性感染明显多于单纯疱疹病毒1型（HSV 1）。HSV 2感染的动物表现出复发频率随时间的显著下降。复发性病变的病毒性质通过感染性HSV的恢复、HSV抗原的检测和组织学检查来证实。原发性感染恢复后，背根神经节和外生殖器皮肤中可发现潜伏性HSV2。豚鼠生殖器HSV感染的复发与人类生殖器疱疹复发具有许多共同特征，并为研究潜伏期与复发之间的关系以及探索控制复发疾病的方法提供了模型。
After recovery from initial genital herpes simplex virus (HSV) infections, female guinea pigs developed spontaneous recurrent infections characterized by discrete erythematous or vesicular herpetic lesions on the external genital skin. HSV type 2 (HSV2) caused significantly more recurrent infections in guinea pigs than did HSV type 1 (HSV1). HSV2-infected animals demonstrated a significant decline in frequency of recurrences over time. The viral nature of the recurrent lesions was confirmed by recovery of infectious HSV, detection of HSV antigen, and histologic examination. Latent HSV2 could be demonstrated in dorsal root ganglia and external genital skin after recovery from the primary infection. Recurrent genital HSV infection in the guinea pig shares many features with recurrent genital herpes in humans and provides a model for studying the relationship between latency and recurrences and for exploring methods for control of recurrent disease.