Modeling the Impact of Abdominal Pressure on Hypoxia in Laboratory Swine
Modeling the Impact of Abdominal Pressure on Hypoxia in Laboratory Swine
复制标题
模拟腹压对实验猪缺氧的影响
DOI：
10.1115/1.4063478
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Friedberg, Joseph S.
中科院分区：
文献类型：
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作者：
KadkhodaeiElyaderani, Behzad;Leibowitz, Joshua L.;Moon, Yejin;Stachnik, Stephen;Awad, Morcos;Sarkar, Grace M.;Shaw, Anna E.;Stewart, Shelby;Culligan, Melissa;Friedberg, Joseph S.
本文提出了一种实验参数化模型的氧气运输的动力学在实验室动物，同时经历：（i）减少吸入氧气加上（ii）增加腹内压。目的是模拟腹内压升高对氧转运动力学的潜在影响。该模型包含三个隔室，即动物的肺、下半身脉管系统和上半身脉管系统。该模型假设腹内压影响心输出量在两个脉管系统隔室之间的分配，并且每个隔室中的有氧代谢随着严重缺氧而减少。拟合这个模型的成年雄性约克郡猪的实验室实验，使用正规化的非线性最小二乘法拟合生理上合理的参数值加上合理的拟合质量。
This paper presents an experimentally parameterized model of the dynamics of oxygen transport in a laboratory animal that simultaneously experiences:(i) a reduction in inspired oxygen plus (ii) an increase in intra-abdominal pressure. The goal is to model the potential impact of elevated intra-abdominal pressure on oxygen transport dynamics. The model contains three compartments, namely, the animal’s lungs, lower body vasculature, and upper body vasculature. The model assumes that intra-abdominal pressure affects the split of cardiac output among the two vasculature compartments and that aerobic metabolism in each compartment diminishes with severe hypoxia. Fitting this model to a laboratory experiment on an adult male Yorkshire swine using a regularized nonlinear least-squares approach furnishes both physiologically plausible parameter values plus a reasonable quality of fit.