Isolation of Candida famata from a patient with acute zonal occult outer retinopathy
Isolation of Candida famata from a patient with acute zonal occult outer retinopathy
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DOI：
10.1128/jcm.43.2.635-640.2005
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发表时间：
2005-02-01
影响因子：
9.4
通讯作者：
González, ME
中科院分区：
文献类型：
--
作者：
Carrasco, L;Ramos, M;González, ME
许多视网膜病变的病因，如急性区域性隐匿性外视网膜病变（AZOOR），仍未确定。从诊断为AZOOR的患者结膜渗出液中分离出famata假丝酵母。这种酵母非常丰富，特别是在受影响更严重的眼睛中，而没有其他病原体或真菌物种的证据。免疫试验显示存在抗原特异性T淋巴细胞通过使用C. famata作为挑战。此外，酶联免疫吸附分析显示，患者血液中存在针对该酵母菌的特异性抗体。皮肤试验的迟发性超敏反应也呈阳性。最后，抗真菌治疗导致一些临床症状的改善，包括眼底镜分析。然而，尽管氟康唑和伊曲康唑治疗时间较长，结膜渗出液中仍出现famata。新的抗真菌药物伏立康唑可能是一种更好的治疗选择。
The etiology of a number of retinopathies, such as acute zonal occult outer retinopathy (AZOOR), remains undetermined. Candida famata was isolated from conjunctival exudates of a patient diagnosed with AZOOR. This yeast was very abundant, particularly in the more affected eye, while no other pathogens or fungal species were in evidence. Immunological tests revealed the presence of antigen-specific T lymphocytes by using C. famata as a challenge. Moreover, enzyme-linked immunosorbent assay analysis showed the presence of specific antibodies against this yeast in the patient's blood. Delayed hypersensitivity by use of a skin test was also positive. Finally, antifungal treatments led to improvements in several clinical symptoms, including funduscopic analysis. However, despite prolonged treatment with fluconazole and itraconazole, C. famata still appeared in the conjunctival exudates. The new antifungal voriconazole may represent a better choice for treatment.