Enhanced sensitivity to the antinociceptive effects of kappa opioids in naltrexone-treated rats: dose- and time-dependent effects.
Enhanced sensitivity to the antinociceptive effects of kappa opioids in naltrexone-treated rats: dose- and time-dependent effects.
复制标题
纳曲酮治疗的大鼠对卡帕阿片类药物的镇痛作用的敏感性增强：剂量和时间依赖性作用。
DOI：
10.1097/00008877-200312000-00008
复制
发表时间：
2003
影响因子：
1.6
通讯作者：
Greene,JL
中科院分区：
文献类型：
--
作者：
Smith,MA;McClean,JM;Greene,JL
The purpose of the present study was to examine sensitivity to the antinociceptive effects of kappa opioids during chronic treatment with the nonselective opioid antagonist naltrexone. In a warm-water tail-withdrawal procedure, rats were restrained and the latencies to remove their tails from water maintained at 50 and 55 C were recorded. Prior to chronic treatment, spiradoline, U50, 488 and (−)-pentazocine produced dose-dependent increases in tail-withdrawal latencies at both 50 and 55 C. Chronic treatment with 3.0 mg/kg naltrexone twice daily (bid) failed to alter sensitivity to the antinociceptive effects of spiradoline when tested 24 h following naltrexone administration. When the maintenance dose of naltrexone was increased to 30 mg/kg bid, sensitivity to the effects of spiradoline was reduced when tested 24 h after naltrexone administration, but enhanced when tested 48 h after naltrexone administration. Enhanced sensitivity was also observed to the antinociceptive effects of U50, 488 and (−)-pentazocine when tested 48 h after chronic treatment with 30 mg/kg naltrexone. After termination of chronic treatment, sensitivity to the antinociceptive effects of spiradoline, U50, 488 and (−)-pentazocine returned to that originally observed prior to naltrexone treatment. These data indicate that chronic naltrexone treatment enhances sensitivity to the antinociceptive effects of kappa opioids, and that this effect is both dose and time dependent.
