More vasomotor symptoms in menopause among women with a history of hypertensive pregnancy diseases compared with women with normotensive pregnancies
More vasomotor symptoms in menopause among women with a history of hypertensive pregnancy diseases compared with women with normotensive pregnancies
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与血压正常妊娠的女性相比，有妊娠高血压病史的女性更年期血管舒缩症状更多
DOI：
10.1097/gme.0b013e3182886093
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发表时间：
2013
期刊：
影响因子：
2.7
通讯作者：
A. Maas
中科院分区：
文献类型：
--
作者：
J. Drost;Y. T. van der Schouw;Gerrie;A. Maas
目的心血管疾病是世界范围内妇女死亡的主要原因。近年来，一些女性特有的心血管危险因素，如妊娠高血压疾病（HPDs）和血管紧张性绝经症状（VMS），已被确定。在这项研究中，我们评估了HPD病史和VMS存在之间的关联。方法我们连续纳入了2003年至2010年期间在坎彭的女性心血管门诊就诊的853名女性（平均年龄55.5岁）。访视包括关于HPD史、人口统计学特征和VMS的问卷调查;体格检查;和血液采样。采用Logistic回归分析。结果274例（32%）有HPD病史，83%有HPD病史，75%无HPD病史。在校正模型中，与血压正常的妊娠妇女相比，有HPD病史的妇女中VMS更常出现（比值比[OR]，1.62; 95%CI，1.00-2.63），且更常持续超过1年（OR，2.05; 95%CI，1.08-3.89）。VMS在有HPD病史的女性中更常见，但这并不显著（校正OR，1.28; 95%CI，0.92-1.80）。VMS的频率和强度在两组之间没有差异。结论在我们的“坎彭妇女心脏病诊所”队列中，有HPD病史的妇女在绝经过渡期报告VMS的频率明显高于血压正常的妊娠妇女。
Objective Cardiovascular disease is the major cause of mortality in women worldwide. In recent years, several female-specific cardiovascular risk factors, such as hypertensive pregnancy diseases (HPDs) and vasomotor menopausal symptoms (VMS), have been identified. In this study, we evaluated the association between a history of HPD and the presence of VMS. Methods We consecutively included 853 women (mean age, 55.5 y) who visited the outpatient cardiovascular clinic for women in Kampen between 2003 and 2010. The visit included a questionnaire on history of HPD, demographic characteristics, and VMS; physical examination; and blood sampling. Logistic regression analysis was used to analyze the data. Results A history of HPD was reported by 274 women (32%), and VMS were reported by 83% of women with a history of HPD and by 75% of women without a history of HPD. In adjusted models, VMS were more often present (odds ratio [OR], 1.62; 95% CI, 1.00-2.63) and more frequently persisted for longer than 1 year (OR, 2.05; 95% CI, 1.08-3.89) among women with a history of HPD than among women with normotensive pregnancies. VMS were more often severe in women with a history of HPD, but this did not reach significance (adjusted OR, 1.28; 95% CI, 0.92-1.80). The frequency and intensity of VMS did not differ between both groups. Conclusions In our “Kampen women cardiology clinic” cohort, women with a history of HPD report VMS during the menopausal transition significantly more often than women with normotensive pregnancies.
妇女健康试验作为一项投资。
DOI：
10.1177/0272989x8900900111
发表时间：
1989
期刊：
Medical decision making : an international journal of the Society for Medical Decision Making
影响因子：
--
作者：
Urban,N;Baker,M
通讯作者：
Baker,M