Nitric oxide is an activity-dependent regulator of target neuron intrinsic excitability.
Nitric oxide is an activity-dependent regulator of target neuron intrinsic excitability.
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DOI：
10.1016/j.neuron.2011.05.037
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发表时间：
2011-07-28
期刊：
影响因子：
16.2
通讯作者：
Forsythe ID
中科院分区：
文献类型：
--
作者：
Steinert JR;Robinson SW;Tong H;Haustein MD;Kopp-Scheinpflug C;Forsythe ID
突触强度的活动依赖性变化被公认为介导学习和记忆的长期可塑性，但靶神经元兴奋性的调节可以补充突触强度的变化并调节网络活动。据认为，稳态机制相匹配的内在兴奋性传入突触驱动，但参与电压门控电导的证据是稀疏的。在这里，我们表明，mesamatergic突触活动调节靶神经元的兴奋性和开关的基础上，动作电位复极从Kv3到Kv2钾通道的优势，从而调整神经元信号之间的低和高活动状态，分别。这种一氧化氮介导的信号传导显著增加听觉脑干和海马两者中的Kv2电流（>3倍），转化突触整合和信息传递，但动作电位波形仅发生适度变化。我们的结论是，一氧化氮是一个稳态调节器，调谐神经元的兴奋性，最近的历史兴奋性突触输入的间隔数分钟至数小时。突触输入驱动NO介导的电压门控钾电流调制高突触活动将显性延迟整流器切换到Kv2 NO体积传递将靶神经元调谐到兴奋性突触驱动这种稳态调节广泛发生在大脑（脑干和海马）
Activity-dependent changes in synaptic strength are well established as mediating long-term plasticity underlying learning and memory, but modulation of target neuron excitability could complement changes in synaptic strength and regulate network activity. It is thought that homeostatic mechanisms match intrinsic excitability to the incoming synaptic drive, but evidence for involvement of voltage-gated conductances is sparse. Here, we show that glutamatergic synaptic activity modulates target neuron excitability and switches the basis of action potential repolarization from Kv3 to Kv2 potassium channel dominance, thereby adjusting neuronal signaling between low and high activity states, respectively. This nitric oxide-mediated signaling dramatically increases Kv2 currents in both the auditory brain stem and hippocampus (>3-fold) transforming synaptic integration and information transmission but with only modest changes in action potential waveform. We conclude that nitric oxide is a homeostatic regulator, tuning neuronal excitability to the recent history of excitatory synaptic inputs over intervals of minutes to hours. ► Synaptic input drives NO-mediated modulation of voltage-gated potassium currents ► High synaptic activity switches the dominant delayed rectifier to Kv2 ► NO volume transmission tunes target neurons to excitatory synaptic drive ► This homeostatic regulation occurs broadly in the brain (brain stem and hippocampus)
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DOI：
10.1073/pnas.89.10.4363
发表时间：
1992-05-15
影响因子：
11.1
作者：
DUDEK, SM;BEAR, MF
通讯作者：
BEAR, MF
影响因子：
5.3
作者：
Artinian, Liana;Tornieri, Karine;Rehder, Vincent
通讯作者：
Rehder, Vincent
影响因子：
3.7
作者：
Fukushima, Fumiaki;Nakao, Kazuhito;Mishina, Masayoshi
通讯作者：
Mishina, Masayoshi
DOI：
10.1073/pnas.94.7.3396
发表时间：
1997-04-01
影响因子：
11.1
作者：
Eliasson, MJL;Blackshaw, S;Snyder, SH
通讯作者：
Snyder, SH
DOI：
10.1073/pnas.95.6.3182
发表时间：
1998-03-17
影响因子：
11.1
作者：
Fenton, AA;Muller, RU
通讯作者：
Muller, RU