Elevated cardiac pressure inhibits renin release after arterial hypotension in conscious dogs.
Elevated cardiac pressure inhibits renin release after arterial hypotension in conscious dogs.
复制标题
意识清醒的狗动脉低血压后，心脏压力升高会抑制肾素释放。
DOI：
10.1152/ajpregu.1984.247.6.r953
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Ramsay,DJ
中科院分区：
文献类型：
--
作者：
Lee,ME;Thrasher,TN;Ramsay,DJ
在头臂动脉近端升主动脉、双侧肾动脉近端腹主动脉或双侧肾动脉近端腹主动脉周围长期植入袖带的犬中，评估了心肺、窦主动脉和肾压力感受器在调节血浆肾素活性（PRA）中的相对作用。调节任意一个袖带的充气，使远端动脉压降低，从而使肾灌注压（RPP）在1小时内分别为对照组的0、5、10、20或30%。通过肾上袖带充气降低RPP （n = 4）导致PRA在整个检查剂量范围内显著（P < 0.05）升高。然而，升主动脉收缩（n = 7）导致相同的RPP降低，却没有增加PRA。这些结果的明显矛盾可能是由于两种操作对左房压的不同影响。左房压在升主动脉袖带膨胀期间呈剂量依赖性增加，但在肾上腺上袖带膨胀期间无变化。为了确定右心房压升高是否会抑制全身性低血压后的肾素释放，另一组狗（n = 4）在肺动脉周围戴上手铐。肺动脉袖带充气引起类似的全身性低血压，导致PRA和RAP显著升高（P < 0.05）。因此，我们得出结论，来自左心的强大抑制信号可以抑制全身性低血压时肾素的释放。
The relative roles of cardiopulmonary, sinoaortic, and renal baroreceptors in the regulation of plasma renin activity (PRA) were evaluated in dogs with chronically implanted cuffs around the ascending aorta proximal to the brachiocephalic artery, the abdominal aorta just proximal to both renal arteries, or both. Inflation of either cuff was adjusted to cause a reduction of distal arterial pressure and hence renal perfusion pressure (RPP) of 0, 5, 10, 20, or 30% of control for 1 h. Reduction of RPP by inflation of the suprarenal cuff (n = 4) led to a significant (P less than 0.05) increase in PRA throughout the dose range examined. However, constriction of the ascending aorta (n = 7) to cause identical reductions in RPP failed to increase PRA. The apparent paradox in these results may be explained by differential effects of the two maneuvers on left atrial pressure. Left atrial pressure increased dose dependently during inflation of the ascending aortic cuff but did not change during inflation of the suprarenal cuff. To determine if elevated right atrial pressure (RAP) would inhibit renin release after systemic hypotension, another group of dogs (n = 4) was prepared with cuffs around the pulmonary artery. Inflation of the pulmonary cuff to cause similar systemic hypotension led to significant (P less than 0.05) increases in PRA and RAP. Therefore we conclude that powerful inhibitory signals, arising from the left heart, can inhibit renin release in response to systemic hypotension.