Preliminary evaluation of nanoscale biogenic magnetite in Alzheimer's disease brain tissue
Preliminary evaluation of nanoscale biogenic magnetite in Alzheimer's disease brain tissue
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DOI：
10.1098/rsbl.2003.0012
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发表时间：
2003-08-07
影响因子：
4.7
通讯作者：
Dobson, J
中科院分区：
文献类型：
--
作者：
Hautot, D;Pankhurst, QA;Dobson, J
铁水平升高与许多类型的神经退行性疾病有关，如阿尔茨海默氏症、帕金森氏症和亨廷顿氏病。然而，这些升高的铁水平不一定与铁储存或转运蛋白、铁蛋白和转铁蛋白的水平升高相关。因此，对这种过量铁的形式知之甚少。最近有人提出，神经退行性组织中的一些过量铁可能以磁性氧化铁磁铁矿（Fe3O4）的形式存在。我们证明，第一次，我们的知识，使用高灵敏度超导量子干涉仪（SQUID）磁力测量，磁铁矿的浓度被发现是显着高于三个样本的阿尔茨海默氏病组织比在三个年龄和性别匹配的控制。这些结果不仅对疾病进展有意义，而且对可能的早期诊断也有意义。
Elevated iron levels are associated with many types of neurodegenerative disease, such as Alzheimer's, Parkinson's and Huntington's diseases. However, these elevated iron levels do not necessarily correlate with elevated levels of the iron storage or transport proteins, ferritin and transferrin. As such, little is known about the form of this excess iron.It has recently been proposed that some of the excess iron in neurodegenerative tissue may be in the form of the magnetic iron oxide magnetite (Fe3O4). We demonstrate, for the first time to our knowledge, using highly sensitive superconducting quantum interference device (SQUID) magnetometry, that the concentrations of magnetite are found to be significantly higher in three samples of Alzheimer's disease tissue than in three age- and sex-matched controls. These results have implications, not only for disease progression, but also for possible early diagnosis.